Protein Alignment nAChRbeta1 and htr3a

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_009293684.1
• Gene: htr3a / 571641
• ZFINID: ZDB-GENE-071012-5
• Length: 482
• Species: Danio rerio
• Alignment Length: 489
• Identity: 132/489 - (26%)
• Similarity: 234/489 - (47%)
• Gaps: 72/489 - (14%)

  Fly    30 RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEA 94
            ||...|..||.|.:|||::..|...|...|....::||:||||::.:.||.|..|.|..|.||..
Zfish    40 RLNEFLSAGYKKGVRPVRDWRQSTTVAIDLMVYAILNVDEKNQVLTTYVWYRQQWTDEFLMWDPE 104

  Fly    95 DYGGIGVLRLPPDKVWKPDIVL--FNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVT 157
            ::..:..:.:|...:|.|||::  |.:...:.::.|   |.:...|.|....|....::|::::.
Zfish   105 EFDEVKKISIPTANIWIPDILINEFVDVGKSPDIPY---VYVGHDGLVSNYKPIQVVTACSLNIY 166

  Fly   158 YFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFV--DLSDYWKSGTWDIIEVPAYLNVYEGDSNH 220
            .||:|.|.|.:.|.||......:::.|..:...|  |.|.:...|.|:::.|.:..|.:..| |.
Zfish   167 NFPYDVQKCSLTFQSWLHTTKDINITLMRSPEAVKTDKSVFMNQGEWELLHVLSTYNAFSID-ND 230

  Fly   221 PTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLV 285
            ....::.|:::|||:.|||||||:||::.:..:.::.||||.::||:|:..|::||...|||::|
Zfish   231 DYYAEMKFHVVIRRRPLFYTVNLLLPSMFLMVMDIVGFYLPPDSGERVSFKITLLLGYSVFLIIV 295

  Fly   286 SKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLF 350
            |..||.|::..|||..|.:....:..:|:..:|:|:....:.....|:|.:::.:.|......|.
Zfish   296 SDTLPATAIGTPLIGVYFVVCMALLVISLTESVLIVRLVHKQDLQSRVPQWVKHLVLEKATVLLC 360

  Fly   351 MKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLH--HPNCKI 413
            ::..:....|                |.||  :||.:      |::.|.    :.:|  |.:|:.
Zfish   361 IRNKKICSFR----------------SQGS--DLPLY------KENNMN----TAIHCNHHSCEG 397

  Fly   414 NRKVNSGGELGLG-----------DGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQ 467
            :|  :||..||||           ||..||                   :..|.:.|..:|...:
Zfish   398 SR--DSGRTLGLGLSAHESGPPVMDGILRE-------------------ITTIRQFLEKKDESRE 441

  Fly   468 TREDWKYVAMVIDRL--QLYIFFIVTTAGTVGIL 499
            ..::|..|..|:|.|  ::|:..::....|:|.|
Zfish   442 IAKEWLQVGYVLDILLFRVYLLTVLAYGITLGSL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	132/489 (27%)
		Neur_chan_LBD	28..236	CDD:280998	60/209 (29%)
		Neur_chan_memb	243..498	CDD:280999	64/269 (24%)
htr3a	XP_009293684.1	LIC	21..479	CDD:273305	132/489 (27%)
		Neur_chan_LBD	40..246	CDD:280998	60/209 (29%)
		Neur_chan_memb	253..479	CDD:280999	66/272 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810