Protein Alignment nAChRbeta1 and CHRNA10

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_065135.2
• Gene: CHRNA10 / 57053
• HGNCID: 13800
• Length: 450
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 165/474 - (34%)
• Similarity: 243/474 - (51%)
• Gaps: 57/474 - (12%)

  Fly    30 RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEA 94
            :|.||||..|...:|||.:..|.:.|...:...|:|:::|:||::...:|:|..|.|..|:||..
Human    32 KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPN 96

  Fly    95 DYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYF 159
            .|||:..:|:|...||:|||||:|.||........:||::...|.|.|..|||.:|||.:||..|
Human    97 AYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAF 161

  Fly   160 PFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYE-GDSNHPTE 223
            |||.|.|.:.|||||..|.|  |.:........|:|:.::..|.::.:||...|.. |..:.| .
Human   162 PFDAQHCGLTFGSWTHGGHQ--LDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEP-Y 223

  Fly   224 TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKI 288
            .|:||.:::||:...|..||:||.||||.|..|.|:|||::||||:||:::||:|.||.||:::.
Human   224 PDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAES 288

  Fly   289 LPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKR 353
            :||...| |||.||.:.|..|.|.|..:|::|:|.::.||....:|.:.|::.|.:|
Human   289 MPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHL-------- 344

  Fly   354 PRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVN 418
            .|...:|...|..|.|.|....||..||.         ||...     .....|.|.|.
Human   345 ARGLCVRERGEPCGQSRPPELSPSPQSPE---------GGAGP-----PAGPCHEPRCL------ 389

  Fly   419 SGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQ 483
                      ||:|:      ||...|:        ||...|:.....:..||||.:|.|:||..
Human   390 ----------CRQEA------LLHHVAT--------IANTFRSHRAAQRCHEDWKRLARVMDRFF 430

  Fly   484 LYIFFIVTTAGTVGILMDA 502
            |.|||.:....::.:|:.|
Human   431 LAIFFSMALVMSLLVLVQA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	163/470 (35%)
		Neur_chan_LBD	28..236	CDD:280998	78/206 (38%)
		Neur_chan_memb	243..498	CDD:280999	83/254 (33%)
CHRNA10	NP_065135.2	LIC	31..442	CDD:273305	163/465 (35%)
		Neur_chan_LBD	32..235	CDD:280998	77/205 (38%)
		Neur_chan_memb	243..434	CDD:280999	80/243 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..380		10/38 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810