Protein Alignment nAChRbeta1 and chrnb5b

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_073778294.1
• Gene: chrnb5b / 569662
• ZFINID: ZDB-GENE-120809-5
• Length: 487
• Species: Danio rerio
• Alignment Length: 497
• Identity: 220/497 - (44%)
• Similarity: 303/497 - (60%)
• Gaps: 47/497 - (9%)

  Fly    15 VLVAFSLVSASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            |.:..:.|..:|.|||||..|..  .|||||||..|.:|:|.:...::..|||:|||:.|||.:|
Zfish    12 VALTMATVWCAEVEERLVNYLLSPDRYNKLIRPAVNKSQQVTIAIQVSLAQLISVNEREQIMTTN 76

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            .||..||.||:|.||..:|.|:..:|||...:|.|||||:|||||.|||.:.||.::...|||.|
Zfish    77 CWLTQVWNDYRLMWDPEEYEGMRKVRLPSQHIWLPDIVLYNNADGTYEVSFYSNAVVSNNGEVAW 141

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEV 207
            :|||||:|:|.|:|..||||||.|.:||.|||::..::.|.|.:  :|....|:..||.|||:.:
Zfish   142 LPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLILLS--DFASRDDFKPSGEWDIVSL 204

  Fly   208 PAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGI 272
            |...|   .|.|..|..|||:..|||||.||||:|||:|.|||:.|.:||||||::.|||:||.|
Zfish   205 PGRKN---EDPNDVTYLDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKITLCI 266

  Fly   273 SILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYI 337
            |:||:|.|||||:|||:|||||.:|||.|||:||.::.|.||:.:|.::|.:.|.|.||.||.::
Zfish   267 SVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHSMPKWV 331

  Fly   338 RSIFLHYLPAFLFMKRP----RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKM 398
            :..||..|||||||:||    ::.|.|            ..|..:.| :::|          .|.
Zfish   332 KYYFLVRLPAFLFMRRPGESNKRDRFR------------RKHQQHSS-SDVP----------VKS 373

  Fly   399 EVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSD-----SILLSPEASKATEAVEFIAEH 458
            |..|.......|      .:|...:|...|  ...|:|:     ::..|.:..:|.:.|.:||:.
Zfish   374 EADEADSTFFVN------EDSANHIGWRAG--ELQENSELRKRMAVKCSADMEEAVKGVRYIADK 430

  Fly   459 LRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            :::||......|||||||||||||.|:||.:|..|||:|:.|
Zfish   431 MKSEDDDEGIIEDWKYVAMVIDRLFLWIFVLVCVAGTIGLFM 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	219/495 (44%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	102/210 (49%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrnb5b	XP_073778294.1	None