Protein Alignment nAChRbeta1 and chrnb5b

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_017214550.1
• Gene: chrnb5b / 569662
• ZFINID: ZDB-GENE-120809-5
• Length: 475
• Species: Danio rerio
• Alignment Length: 460
• Identity: 198/460 - (43%)
• Similarity: 277/460 - (60%)
• Gaps: 47/460 - (10%)

  Fly    15 VLVAFSLVSASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            |.:..:.|..:|.|||||..|..  .|||||||..|.:|:|.:...::..|||:|||:.|||.:|
Zfish    12 VALTMATVWCAEVEERLVNYLLSPDRYNKLIRPAVNKSQQVTIAIQVSLAQLISVNEREQIMTTN 76

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            .||..||.||:|.||..:|.|:..:|||...:|.|||||:|||||.|||.:.||.::...|||.|
Zfish    77 CWLTQVWNDYRLMWDPEEYEGMRKVRLPSQHIWLPDIVLYNNADGTYEVSFYSNAVVSNNGEVAW 141

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEV 207
            :|||||:|:|.|:|..||||||.|.:||.|||::..::.|.|.:  :|....|:..||.|||:.:
Zfish   142 LPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLILLS--DFASRDDFKPSGEWDIVSL 204

  Fly   208 PAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGI 272
            |...|   .|.|..|..|||:..|||||.||||:|||:|.|||:.|.:||||||::.|||:||.|
Zfish   205 PGRKN---EDPNDVTYLDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKITLCI 266

  Fly   273 SILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYI 337
            |:||:|.|||||:|||:|||||.:|||.|||:||.::.|.||:.:|.::|.:.|.|.||.||.::
Zfish   267 SVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHSMPKWV 331

  Fly   338 RSIFLHYLPAFLFMKRP----RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKM 398
            :..||..|||||||:||    ::.|.|            ..|..:.| :::|          .|.
Zfish   332 KYYFLVRLPAFLFMRRPGESNKRDRFR------------RKHQQHSS-SDVP----------VKS 373

  Fly   399 EVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSD-----SILLSPEASKATEAVEFIAEH 458
            |..|.......|      .:|...:|...|  ...|:|:     ::..|.:..:|.:.|.:||:.
Zfish   374 EADEADSTFFVN------EDSANHIGWRAG--ELQENSELRKRMAVKCSADMEEAVKGVRYIADK 430

  Fly   459 LRNED 463
            :::||
Zfish   431 MKSED 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	198/460 (43%)
		Neur_chan_LBD	28..236	CDD:280998	102/209 (49%)
		Neur_chan_memb	243..498	CDD:280999	87/230 (38%)
chrnb5b	XP_017214550.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920