Protein Alignment nAChRbeta1 and chrna2b

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_697298.4
• Gene: chrna2b / 568849
• ZFINID: ZDB-GENE-041001-99
• Length: 550
• Species: Danio rerio
• Alignment Length: 538
• Identity: 237/538 - (44%)
• Similarity: 331/538 - (61%)
• Gaps: 56/538 - (10%)

  Fly     9 LLCSILV-LVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72
            |||:|:. .::....:.|..|:.|.:.||.||||..|||.|.:..|.|:|||:..|||:|:||||
Zfish    15 LLCTIICESISCCEKTHSHAEDELFKKLFDGYNKWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQ 79

  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137
            :|.:||||:..|.||:|:|..:||..:..:|:|.:.:|.|||||:|||||.:.|.:.:...::.|
Zfish    80 MMTTNVWLKQEWNDYKLRWKPSDYDNVTSIRVPSELIWVPDIVLYNNADGEFAVTHMTKAHLFHT 144

  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTW 202
            |:|.|||||||:|||:||||:||||||.|.|||||||:  |:..:.|...:|.|||.|||:||.|
Zfish   145 GKVRWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTY--DKAKIDLERIENTVDLKDYWESGEW 207

  Fly   203 DIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEK 267
            .||......|..:.|..|....|||::.||||..||||:|||:|.:|||.|.|||||||::.|||
Zfish   208 AIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEK 272

  Fly   268 VTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR 332
            :||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|.:.|.|.||:
Zfish   273 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHK 337

  Fly   333 MPMYIRSIFLHYLPAFLFMKRP------RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI 391
            ||.::.|:||..:|.:|||:||      |:..|....::|||:  |.|     :.|.|....|..
Zfish   338 MPCWVHSVFLDLIPRWLFMRRPAPDSRRRQKLLLLQRQVPGMT--ARP-----ANASLSTSTSWF 395

  Fly   392 GGKQS---------KMEVMELSDLHHPNCKINRKVNSGGELGL--------GDGCRRE------- 432
            .|:.|         ..:.:||..|... ..::.:.:|...|||        |...|.|
Zfish   396 RGQNSGEDESCRHFSYKDLELGTLSSA-ISLSLQASSPCPLGLTPPPLQKFGPAPRLEVGTASRQ 459

  Fly   433 -------SESSDSIL--------LSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRL 482
                   ::..|:::        |||...:|.|.|.:||:|||.||.....:||||||||||||:
Zfish   460 LSGRANVTKRLDNMIPHDNPGFPLSPSVLQALEGVHYIADHLRAEDADFSVKEDWKYVAMVIDRI 524

  Fly   483 QLYIFFIVTTAGTVGILM 500
            .|::|.||...||:|:.:
Zfish   525 FLWMFIIVCLLGTIGLFL 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	237/536 (44%)
		Neur_chan_LBD	28..236	CDD:280998	106/207 (51%)
		Neur_chan_memb	243..498	CDD:280999	120/299 (40%)
chrna2b	XP_697298.4	LIC	6..543	CDD:273305	237/538 (44%)
		Neur_chan_LBD	35..241	CDD:280998	106/207 (51%)
		Neur_chan_memb	248..541	CDD:280999	121/300 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920