DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta1 and chrna3

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_001921314.1	Gene:	chrna3 / 568467	ZFINID:	ZDB-GENE-070822-1	Length:	508	Species:	Danio rerio

Alignment Length:	507	Identity:	228/507 - (44%)
Similarity:	328/507 - (64%)	Gaps:	39/507 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIM 74
            ||.:|     |.|..||.|.||...:|..||:.||||:|::..|.|:|.::..||:.|:|.||||
Zfish    16 LCFLL-----SGVCCSEAEHRLFSVIFSSYNQYIRPVENVSDPVVVQFEVSMSQLVKVDEVNQIM 75

  Fly    75 KSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGE 139
            ::|:|||.:|.||:|:||..|:||:..:|:|.:|:|||||||:|||.|:::|..|:..|:...|:
Zfish    76 ETNLWLRHIWNDYKLRWDPKDFGGVEFIRVPSNKIWKPDIVLYNNAVGDFQVDDKTKALLRFNGD 140

  Fly   140 VLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDI 204
            |.|:||||::|||.|||||||||.|.|.|||||||::..::.|.|..:.  ::|.|:|:||.|.|
Zfish   141 VTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVLIGST--INLKDFWESGEWTI 203

  Fly   205 IEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVT 269
            |:.|.|.:..:.:......||||:.:.|||..||||:|:|:|.:|||||.|||||||::.|||||
Zfish   204 IDAPGYKHDIKYNCCEEIYTDITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPSDCGEKVT 268

  Fly   270 LGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMP 334
            |.||:||||.||||::::.:|.||||:|||.:|||||.|..|:||::||.::|.::|.|:||.||
Zfish   269 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKTHTMP 333

  Fly   335 MYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKME 399
            .::|.:||..||..:||.||.|.:     |:|......||..|       .|..|...|.|..:.
Zfish   334 CWVRRVFLSLLPRVMFMTRPEKDQ-----EVPAKQCSVHPPVS-------SKQTSVCRGPQLLLC 386

  Fly   400 VMELSDL---------HHPNC---KINRKVNSGGELGLGDGCRRESESSDSIL----LSPEASKA 448
            ..||::.         ||  |   .|:...:.|.|.| |..| ..|||.|..|    :||:..:|
Zfish   387 PTELNEASRTAFLCREHH--CWKKHISNMTSEGAEDG-GSPC-SSSESLDGFLCMSAVSPQVREA 447

  Fly   449 TEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            .|:|::|||::|.::...:.::|||||||||||:.|::|.:|...||.|:.:
Zfish   448 IESVKYIAENMRLQNEAKEVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	228/505 (45%)
		Neur_chan_LBD	28..236	CDD:280998	99/207 (48%)
		Neur_chan_memb	243..498	CDD:280999	116/270 (43%)
chrna3	XP_001921314.1	LIC	4..499	CDD:273305	228/505 (45%)
		Neur_chan_LBD	29..235	CDD:280998	99/207 (48%)
		Neur_chan_memb	242..498	CDD:280999	117/271 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020