Protein Alignment nAChRbeta1 and chrnb2

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_005169811.1
• Gene: chrnb2 / 561906
• ZFINID: ZDB-GENE-070821-3
• Length: 543
• Species: Danio rerio
• Alignment Length: 534
• Identity: 220/534 - (41%)
• Similarity: 303/534 - (56%)
• Gaps: 53/534 - (9%)

  Fly     8 WLLCSILVLVAFSLVSASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            |.|..||.:|....  .::.|||||..|..  .|||||||..|.::.|.|:..::..|||:|:|:
Zfish     5 WTLFCILAIVKSGY--GADTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQLISVHER 67

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            .|||.:||||...|.||:|.|...::.|:..:|||...:|.||:||:|||||.|||.:.||.::.
Zfish    68 EQIMTTNVWLTQEWQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVS 132

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSG 200
            ..|.|.|:|||||:|:|.|:|.:||||||.|.:.|.|||::..:|.|.|  ..:...:.|:..||
Zfish   133 YDGSVFWLPPAIYKSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVL--RADVASMDDFTPSG 195

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            .||||.:|...|....|   ||..|||:..|||||.||||:|||:|.|||:.|.:||||||::.|
Zfish   196 EWDIIALPGRRNENPSD---PTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCG 257

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            ||:||.||:||:|.|||||:|||:|||||.:||:.|||:||.::.|.||:.:|.::|.:.|.|.|
Zfish   258 EKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT 322

  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQ 395
            |.||.:::.:||:.|||.|||::||.:..|..:.....:.........|..|.|...:...|...
Zfish   323 HTMPPWVKLVFLNKLPALLFMRQPRNSSERQRLRQRRRANEQQEGGRGGLAAGLMAGLGLSGSSS 387

  Fly   396 SKMEVMELSDLHHPNCKINRK--VNSGGELGLGDGCRRESESSDSI------------------- 439
            ...|..|..     .|.:||.  ...|.|||.|.|....::..:.|
Zfish   388 GSKENNEAC-----TCYVNRASVKQFGAELGGGGGGGGSTDGLNGIREGGRETREGGANPLQGSA 447

  Fly   440 ---------------LLS---PEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYI 486
                           ||:   |...:|.:.|.|||.|:::||......|||||||||||||.|:|
Zfish   448 LPRGKQQPPTVLTQALLAQACPGFEEAVDGVRFIANHMKSEDDDRSVSEDWKYVAMVIDRLFLWI 512

  Fly   487 FFIVTTAGTVGILM 500
            |..|...||:|:.:
Zfish   513 FVFVCVFGTIGMFL 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	220/532 (41%)
		Neur_chan_LBD	28..236	CDD:280998	97/209 (46%)
		Neur_chan_memb	243..498	CDD:280999	111/293 (38%)
chrnb2	XP_005169811.1	LIC	4..526	CDD:273305	220/532 (41%)
		Neur_chan_LBD	23..228	CDD:280998	97/209 (46%)
		Neur_chan_memb	235..525	CDD:280999	112/294 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.780