DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta1 and chrna10a

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_021337092.1	Gene:	chrna10a / 556507	ZFINID:	ZDB-GENE-060503-725	Length:	532	Species:	Danio rerio

Alignment Length:	504	Identity:	157/504 - (31%)
Similarity:	270/504 - (53%)	Gaps:	57/504 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDE 93
            ::|:.|||..|...:|||::....:.|...:...|:|:::|:|||:.:.:|:|.||.|..|.|::
Zfish    31 QKLLNDLFNNYTSALRPVEDTEDILNVTLQITLSQIIDMDERNQILTAYLWIRQVWIDKYLTWNK 95

  Fly    94 ADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTY 158
            .:|.|:..:|:|...||:|||||:|:||.::.....:||:|...|:::|..|||.:|||.:||::
Zfish    96 ENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDTNVVIRHDGQIMWDAPAITKSSCKVDVSF 160

  Fly   159 FPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTE 223
            ||||.|.|.:.:||||:||:|  |.:.|.....||:|...:..|:::.:||..|:..........
Zfish   161 FPFDAQQCRLTYGSWTYNGNQ--LDILNAMESADLADLVDNVEWEVLGMPAKRNIILYGCCADPY 223

  Fly   224 TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKI 288
            .|:|:.:.::|:..||..||::|.|:||||..|.|||||::||||:||::::|:|.||.|||::|
Zfish   224 PDVTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPADSGEKVSLGVTVMLALTVFQLLVAEI 288

  Fly   289 LPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKR 353
            :||:..| |||.||.:.|..|.|.|..:|:.::|.:..||....:|.:.:...|.||
Zfish   289 MPPSENV-PLIGKYYIATMTMITASTALTIFVMNIHHCGPDAKPVPDWAKKFILQYL-------- 344

  Fly   354 PRKTRLRWMMEMPGMSM---PAHPHPSYGSPAELPKHISAIGGKQ------------SKMEVME- 402
               .|:.::.|:....|   |..|.|....|.:...:::...||.            :..:::|
Zfish   345 ---ARICFVYEVGENCMTPQPEKPDPQPQKPQDCNCNMNGQAGKDDFVFKFDRNQEATSPKLLED 406

  Fly   403 ---LSDLHHPNCKINR----------------------KVNSGGELGLG-DGCRRESESSDSILL 441
               :|.:..|.|.:.:                      ...:|..:|.| :|| |:.:|......
Zfish   407 REDMSQILSPACSLGKHPTCRYGVWKEGVFMSMDCGDGAAETGKPIGRGQEGC-RDHDSGFKSQC 470

  Fly   442 SPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIV 490
            ..:.......:|::|...|::....:...:||.||.|:||..:::|||:
Zfish   471 KCDQQHLLRNIEYVANCYRDQRATARRTGEWKKVAKVLDRFFMWLFFIM 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	157/504 (31%)
		Neur_chan_LBD	28..236	CDD:280998	74/206 (36%)
		Neur_chan_memb	243..498	CDD:280999	80/290 (28%)
chrna10a	XP_021337092.1	Neur_chan_LBD	31..422	CDD:332142	137/404 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810