Protein Alignment nAChRbeta1 and CHRNA9

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_060051.2
• Gene: CHRNA9 / 55584
• HGNCID: 14079
• Length: 479
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 178/513 - (34%)
• Similarity: 282/513 - (54%)
• Gaps: 54/513 - (10%)

  Fly     4 SCKS--WLLCSILVLVAFSLVSASED-----EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAF 61
            ||.|  |      :..|.|.:.|:|.     .::|..|||..|:..:|||::..:.:.|...:..
Human     6 SCISFCW------IYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITL 64

  Fly    62 VQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEV 126
            .|:.:::|:|||:.:.:|:|.:|:|..|.||...|.|:..:|:|.|.||:|||||:|.||.....
Human    65 SQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSE 129

  Fly   127 RYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFV 191
            ...:||::...|.:.|..|||.:|||.:||||||||.|.|.:.|||||:||:||.  ::|..:..
Human   130 PVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVD--IFNALDSG 192

  Fly   192 DLSDYWKSGTWDIIEVPAYLNVYE-GDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCV 255
            ||||:.:...|::..:||..||.. |..:.| ..|:||.::::|::.||.|||::|.||||||..
Human   193 DLSDFIEDVEWEVHGMPAVKNVISYGCCSEP-YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAP 256

  Fly   256 LVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVII 320
            |.|||||.:||||:||::|||::.||.|:|::|:|.:..| |||.||.:.|..:.|.|..:|:::
Human   257 LSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMV 320

  Fly   321 INWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELP 385
            :|.:|.|.....:|.:.|.:.|.|:...||:....::.|             .||.|     ...
Human   321 MNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCL-------------SPHHS-----RER 367

  Fly   386 KHISAIGGK--QSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCR----RESESSDSILLSPE 444
            .|::.:..|  :|.::.....||       :||.:....|....||:    :|:||     ...:
Human   368 DHLTKVYSKLPESNLKAARNKDL-------SRKKDMNKRLKNDLGCQGKNPQEAES-----YCAQ 420

  Fly   445 ASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            ....|..:|:||:.|::.........:||.||.||||..::||||:....|:.|:..|
Human   421 YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	174/503 (35%)
		Neur_chan_LBD	28..236	CDD:280998	81/208 (39%)
		Neur_chan_memb	243..498	CDD:280999	83/260 (32%)
CHRNA9	NP_060051.2	LIC	10..474	CDD:273305	173/503 (34%)
		Neur_chan_LBD	31..236	CDD:280998	80/207 (39%)
		Neur_chan_memb	244..474	CDD:280999	83/260 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810