Protein Alignment nAChRbeta1 and chrna6

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001036149.1
• Gene: chrna6 / 555747
• ZFINID: ZDB-GENE-090312-91
• Length: 512
• Species: Danio rerio
• Alignment Length: 512
• Identity: 220/512 - (42%)
• Similarity: 328/512 - (64%)
• Gaps: 37/512 - (7%)

  Fly     8 WLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72
            :||.:::....||    |:.|:||.|.|||.||:.||||:|::..|.|.|.::..||:.|:|.||
Zfish    11 FLLITLITQDCFS----SKGEDRLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVNQ 71

  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137
            ||::|:|||.:|.||:|:|..|::.||..:|:|.:|:|:|||||:|||.|::.|..|:..|:...
Zfish    72 IMETNLWLRHIWNDYKLKWSPAEFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKFD 136

  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTW 202
            |.:.||||||::|||.:|:||||||.|.|.|||||||::..::.|.|..:|  |:|.|:|:||.|
Zfish   137 GTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVLIGSK--VNLKDFWESGEW 199

  Fly   203 DIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEK 267
            :||:.|.|.:..:.:.......|||:...|||..||||:|||:|.:|||||.|||||||::.|||
Zfish   200 EIIDAPGYKHDIKYNCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEK 264

  Fly   268 VTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR 332
            |||.||:||||.||||::::.:|.||||:|||.:|||||.|..|:||::||.::|.::|.|.||.
Zfish   265 VTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMTHT 329

  Fly   333 MPMYIRSIFLHYLPAFLFMKRP---RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGK 394
            ||.::.::||..||..:.|:||   .::..:..:|..|.|     ....|...|..|..:: |.:
Zfish   330 MPSWVHTVFLRALPRIMLMRRPLDLSESSGKGGLETGGSS-----GTGAGRGGEGKKRKNS-GSQ 388

  Fly   395 QSKMEVMELSDLHHPNCKINRKVNSGG-------ELGLGDGCRRESE--SSDSI-------LLSP 443
            |..|..:|..:     .|...:...||       |...|| |.:.|.  |..:|       ::||
Zfish   389 QGAMNSLEFGE-----GKAALEGKKGGCPCHPLKEATEGD-CGKVSRQLSPQAINTVVAFSVVSP 447

  Fly   444 EASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            |..:|.|:|::|||::|:.:...:..:|||||||||||:.|::|.:|...||:|:.:
Zfish   448 EIKQAIESVKYIAENMRSRNKAKEVEDDWKYVAMVIDRIFLWVFVLVCVLGTLGLFL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	220/510 (43%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	99/208 (48%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrna6	NP_001036149.1	LIC	38..504	CDD:455710	208/479 (43%)
		LGIC_ECD	38..233	CDD:475126	92/196 (47%)