Protein Alignment nAChRbeta1 and chrna5

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001017885.1
• Gene: chrna5 / 550584
• ZFINID: ZDB-GENE-050417-440
• Length: 466
• Species: Danio rerio
• Alignment Length: 509
• Identity: 193/509 - (37%)
• Similarity: 290/509 - (56%)
• Gaps: 78/509 - (15%)

  Fly     9 LLCSILVLVAFS---LVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            |:||.::..|..   |.|.::.|::|.:.||..|.|.:||::::...:.|:||||..||::|:||
Zfish    14 LVCSAVLCSAIGPPMLSSYAKTEDKLFKHLFSNYQKWVRPIEDLNTTIQVKFGLAISQLVDVDEK 78

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            ||:|.:|||::..|.|.:|:||...|.||..:|:|.|.:|.|||||::|||||:|......|:.:
Zfish    79 NQLMTTNVWMKQEWTDLKLRWDPDHYLGITSIRVPSDSIWIPDIVLYDNADGNFEATVTKAVVRF 143

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSG 200
             .|.:.|.|||.|:|:||||||:||||.|.|.|||||||::|.||.:.|  ....||..||:.:|
Zfish   144 -DGTISWTPPANYKSACTIDVTFFPFDLQNCSMKFGSWTYDGSQVDILL--EDVHVDKRDYFDNG 205

  Fly   201 TWDIIEVPAYLNV-YEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
            .|:|::......: .:|...:|:   ||:..||||..||||:.||:|.:.:|||.|||||||:..
Zfish   206 EWEIVKATGNRGLRRDGTFFYPS---ITYSFIIRRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNG 267

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |||::|..|:|:||.||||::.:|:|.:|.|:|||.:||:||.|..|:||::||..||.:.|...
Zfish   268 GEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSS 332

  Fly   330 THR-MPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGG 393
            ||. |..::|.||||:||..|.|:                   :|
Zfish   333 THHSMAPWVRRIFLHHLPRLLCMR-------------------SH-------------------- 358

  Fly   394 KQSKMEVMELSDLHHPNCKINRKVNSGGEL--GLGDGCRRESESSDSILLSPE--ASKATEAVEF 454
                               ::|...|.|..  |||.|   :|.|.|:..|..|  ...|.|::.:
Zfish   359 -------------------VDRYATSAGTRTGGLGYG---KSLSQDTNQLDAEHNLQAALESIRY 401

  Fly   455 IAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEY 508
            |..|:..|:...:..:|||:||.|:||:.|:.|.:|:..|:.  |:..|.|:::
Zfish   402 ITRHVVKENEVREVVQDWKFVAQVLDRVFLWAFLLVSLLGSA--LLFIPVIYKW 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	190/499 (38%)
		Neur_chan_LBD	28..236	CDD:280998	93/208 (45%)
		Neur_chan_memb	243..498	CDD:280999	87/259 (34%)
chrna5	NP_001017885.1	LIC	12..448	CDD:273305	191/502 (38%)
		Neur_chan_LBD	36..239	CDD:280998	93/208 (45%)
		Neur_chan_memb	246..446	CDD:280999	88/262 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820