Protein Alignment nAChRbeta1 and Chrnd

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_062171.1
• Gene: Chrnd / 54240
• RGDID: 2352
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 545
• Identity: 192/545 - (35%)
• Similarity: 303/545 - (55%)
• Gaps: 80/545 - (14%)

  Fly     9 LLCSILVLVAFSLVSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            ||.:::|..::.|    .:|:||::.||  :||||.:|||......|.|...|....||::.|..
  Rat    10 LLAALVVCGSWGL----NEEQRLIQHLFEEKGYNKELRPVARKEDIVDVALSLTLSNLISLKEVE 70

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            :.:.:|||:...|.|.:|||:..::|.|.|||||.|.||.|:|||.||.||::::.|..|||:..
  Rat    71 ETLTTNVWIDHAWIDSRLQWNANEFGNITVLRLPSDMVWLPEIVLENNNDGSFQISYACNVLVSD 135

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL----YNNKNF------V 191
            :|.|.|:||||::|||.|.|||||||.|.|.:||.|..:...::.|:|    .:|:::      :
  Rat   136 SGHVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIRLSLKQEEEDNRSYPIEWIII 200

  Fly   192 DLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTET----DITFYIIIRRKTLFYTVNLILPTVLISF 252
            |...:.::|.|:|:...|.:||   |.:.|.::    |:|||:|||||.|||.:|:::|.|||||
  Rat   201 DPEGFTENGEWEIVHRAAKVNV---DPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISF 262

  Fly   253 LCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVT 317
            :..||||||.:.|||.::.||:||:..|||||:||.||.||:.:||:.|:|||..::.|:.:::.
  Rat   263 MINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVIC 327

  Fly   318 VIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPA 382
            ||::|.:||.|.||.:...::..||..||..|.|.||.:       |.||             |.
  Rat   328 VIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPEE-------EDPG-------------PR 372

  Fly   383 ELPKHISAIG---------GKQSKMEVM--ELSDLHHPNCKINRKVNSGGELGLGDGCRRESESS 436
            .|.:..|::|         ..:|:.::|  :.|:.|    .:.|::.:         .|:...||
  Rat   373 ALIRRTSSLGYISKAEEYFSLKSRSDLMFEKQSERH----GLARRLTT---------ARKPPASS 424

  Fly   437 DSIL--LSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGIL 499
            :.:.  |..|...|.:...||..|:|:::.|.:.:::|..||..:|||.|::...|...||..|.
  Rat   425 EQVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIF 489

  Fly   500 MDAPH-----------IFEYVDQDR 513
            :...:           .|.|.:|||
  Rat   490 LQGVYNQPPPQPFPGDPFSYDEQDR 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	187/519 (36%)
		Neur_chan_LBD	28..236	CDD:280998	91/223 (41%)
		Neur_chan_memb	243..498	CDD:280999	86/267 (32%)
Chrnd	NP_062171.1	LIC	23..476	CDD:273305	179/488 (37%)
		Neur_chan_LBD	25..246	CDD:280998	91/223 (41%)
		Neur_chan_memb	253..489	CDD:280999	86/268 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810