Protein Alignment nAChRbeta1 and Chrnb2

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_062170.1
• Gene: Chrnb2 / 54239
• RGDID: 2350
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 522
• Identity: 216/522 - (41%)
• Similarity: 296/522 - (56%)
• Gaps: 87/522 - (16%)

  Fly    14 LVLVAFSL------VSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            :.|.:|||      |..::.|||||..|.  ..|||||||..|.::.|.|:..::..|||:|:|:
  Rat     8 MALFSFSLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHER 72

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            .|||.:||||...|.||:|.|...|:..:..:|||...:|.||:||:|||||.|||.:.||.::.
  Rat    73 EQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVS 137

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSG 200
            ..|.:.|:|||||:|:|.|:|.:||||||.|.|||.|||::..::.|.|  ..:...|.|:..||
  Rat   138 YDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--KSDVASLDDFTPSG 200

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            .||||.:|...|....||   |..|||:..|||||.||||:|||:|.|||:.|.:||||||::.|
  Rat   201 EWDIIALPGRRNENPDDS---TYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCG 262

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            ||:||.||:||:|.|||||:|||:|||||.:||:.|||:||.::.|.||:.:|.::|.:.|.|.|
  Rat   263 EKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT 327

  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPR------KTRLR------------WMMEMPGMSMPAHPHPS 377
            |.|..:::.:||..||..||:::||      :.|||            :..|.|.    |.|...
  Rat   328 HTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGALFFREGPA----ADPCTC 388

  Fly   378 YGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLS 442
            :.:||.:.                                      ||....|.|..::     .
  Rat   389 FVNPASVQ--------------------------------------GLAGAFRAEPTAA-----G 410

  Fly   443 PEAS---------KATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGI 498
            |..|         :|.:.|.|||:|:|:||.....||||||||||||||.|:||..|...||||:
  Rat   411 PGRSVGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGM 475

  Fly   499 LM 500
            .:
  Rat   476 FL 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	216/520 (42%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	98/210 (47%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
Chrnb2	NP_062170.1	LIC	28..477	CDD:455710	211/500 (42%)
		LGIC_ECD_nAChR_B2	30..233	CDD:349826	96/207 (46%)
		Cys-loop	154..168	CDD:349826	9/13 (69%)