DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and Chrna10

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_001074893.1 Gene:Chrna10 / 504186 MGIID:3609260 Length:447 Species:Mus musculus


Alignment Length:491 Identity:165/491 - (33%)
Similarity:245/491 - (49%) Gaps:60/491 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 ILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            :|.|.|..|.:......:|.||||..|...:|||.:..|.:.|...:...|:|:::|:||::...
Mouse    15 LLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLY 79

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            :|:|..|.|..|.||...||.:..:|:|...||:|||||:|.||........:||::...|.|.|
Mouse    80 LWIRQEWTDAYLHWDPKAYGDLDAIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRW 144

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEV 207
            ..|||.:|||.:||:.||||.|.|.:.|||||..|.|:.:......  ..|:|:.::..|.::.:
Mouse   145 DAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTS--ASLADFVENVEWRVLGM 207

  Fly   208 PAYLNVYE-GDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLG 271
            ||...|.. |..:.| ..|:||.:::||:...|..||:||.|.||.|..|.|:|||::||||:||
Mouse   208 PARRRVLTYGCCSEP-YPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLG 271

  Fly   272 ISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMY 336
            :::||:|.||.|::::.:||...| |||.||.:.|..|.|.|..:|::|:|.::.||..|.:|.:
Mouse   272 VTVLLALTVFQLILAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAW 335

  Fly   337 IRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVM 401
            .|.:.|.:|...|.        :|...|..|.|.|....||...||..|                
Mouse   336 ARVLLLGHLAKGLC--------VRERGEPCGQSKPLESAPSLQPPAGPP---------------- 376

  Fly   402 ELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYI 466
             ....|.|.|.                |.:|:      ||...||        ||...|:.....
Mouse   377 -AGPCHEPRCL----------------CHQEA------LLHHVAS--------IAGTFRSHRAAQ 410

  Fly   467 QTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            :..||||.:|.|:||..|.|||.:....::.:|:.|
Mouse   411 RRHEDWKRLARVMDRFFLGIFFCMALVMSLLVLVQA 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 163/487 (33%)
Neur_chan_LBD 28..236 CDD:280998 76/208 (37%)
Neur_chan_memb 243..498 CDD:280999 81/254 (32%)
Chrna10NP_001074893.1 LGIC_ECD 30..236 CDD:355788 76/208 (37%)
LGIC_TM_cation 239..>324 CDD:349853 41/85 (48%)
TM1 helix 239..261 CDD:349853 11/21 (52%)
Neur_chan_memb 243..437 CDD:367256 81/249 (33%)
TM2 helix 269..290 CDD:349853 8/20 (40%)
TM3 helix 300..322 CDD:349853 8/21 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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