Protein Alignment nAChRbeta1 and chrne

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001314812.1
• Gene: chrne / 445315
• ZFINID: ZDB-GENE-040808-32
• Length: 517
• Species: Danio rerio
• Alignment Length: 518
• Identity: 172/518 - (33%)
• Similarity: 275/518 - (53%)
• Gaps: 68/518 - (13%)

  Fly    14 LVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNV 78
            :.|:|..|.....:|.:|:.|.|:.|:|.|||.::..:||.|:..|....||::|||.:.:.:||
Zfish    15 IALLATVLQVTGNEESQLIADKFKNYSKNIRPARHADEKVKVQVKLTLTNLISLNEKEETLTTNV 79

  Fly    79 WLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWV 143
            |:.:.|:||:|.|:.::|..|..:|:|...||.|||||.||.||.::|.|.:||||...|.:.|:
Zfish    80 WIEIQWHDYRLAWNTSEYHDIEQIRVPYYTVWLPDIVLENNIDGKFDVAYYANVLISSDGSMYWL 144

  Fly   144 PPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN-----FVDLSD--YWKSGT 201
            |||||:|:|.|::||||||.|.|.:.|.|.|::.:::.:.|..::|     :||:..  :.::|.
Zfish   145 PPAIYRSTCAIEITYFPFDWQNCTLVFRSQTYSANEIDIVLAEDENGKPIEWVDIDPEAFTENGE 209

  Fly   202 WDIIEVPAYLNVYEGDSNHPTETDITFY-IIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA- 264
            |.|...||.....:..|....|....:| |||:||.|||.:|:|||..|||.|.||.::|||:|
Zfish   210 WAIKHRPARKLTNQRYSPDDLEYQEVYYNIIIQRKPLFYVINIILPCSLISSLVVLAYFLPAKAG 274

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |:|:|:.||:||:..|||:|:|:.:|.|||.:|||.|||:|...|.|:.:...:|::|::.|.|.
Zfish   275 GQKLTVSISVLLAQTVFLILISQKIPETSLSVPLIGKYLIFVMSMTTLIVTNCIIVLNYSLRSPS 339

  Fly   330 THRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMS-------------MPAHPHPSYGSP 381
            ||.|...|:.|||..:|.:|                 ||:             |......|:|..
Zfish   340 THNMSQSIKHIFLEVVPRYL-----------------GMAPFVDEGDQGGVYEMRERRRSSFGLM 387

  Fly   382 AELPKHISAIGGKQSKMEVM--ELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILL--- 441
            ....:::.    ||.:.|:|  :..:.|                ||......|.:.|.:..|
Zfish   388 QRAEEYVL----KQPRSEMMFDKQRERH----------------GLMRTIVDEIDVSSTANLYKS 432

  Fly   442 ----SPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
                :||..:..:|..||||..:.::......|.|..:..:||::..:....:.:.||:.|.:
Zfish   433 LAKTAPEIKECVDACNFIAESTKQQNDTGSEMESWVLIGKMIDKVCFWAAISLFSIGTIAIFL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	172/516 (33%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	84/216 (39%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrne	NP_001314812.1	LGIC_ECD_nAChR_G	52..245	CDD:349830	75/192 (39%)
		Cys-loop	153..167	CDD:349830	9/13 (69%)
		Neur_chan_memb	252..494	CDD:460753	79/278 (28%)