Protein Alignment nAChRbeta1 and NtR

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 432
• Identity: 86/432 - (19%)
• Similarity: 158/432 - (36%)
• Gaps: 91/432 - (21%)

  Fly    14 LVLVAFSLVSASEDEERLVRDL-FRGYNKLIRPV---QNMTQKVGVRFGLAFVQLINVNEKNQIM 74
            ||:...|..|...:..|...|. |.||...|.|:   :..|:|:        :..:|:..:|..|
  Fly   176 LVINYLSFSSFGSNTARWFYDCGFDGYGSEIAPIVKEETKTEKL--------LSHLNIQAENASM 232

  Fly    75 KSN-------------------------VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDI 114
            .:|                         :.:.:.|.|.:|.|...|:|.:.....|..::|||.:
  Fly   233 PANLSSISFHFQTRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHM 297

  Fly   115 VLFNNA-DGNYEVRYKSNVLIYPTGEV-LWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNG 177
            .:.|.| ....:|.....:::|..|.: |:.......|.|......:|.::.||.::.|   .||
  Fly   298 NVLNGALQSMGQVLQSYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELG---LNG 359

  Fly   178 D--QVSLAL-YNNK-------NFVDLSDYWKSGTWDIIEVPAYLNVYEGDSN---------HPTE 223
            .  |.::|| |:::       ..|:....|......::.|       |.||.         ....
  Fly   360 QEGQENVALIYDDQRKPIAPNEHVNTPSGWSFTQMSVVLV-------ENDSQRRYNPKGMMQKMT 417

  Fly   224 TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVF---LLLV 285
            .|:.....::|...||.....||.:......:|.|.|.:.....:     ||::|::.   |:.:
  Fly   418 GDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVLRSTRRSSL-----ILIALLIAAWGLMYM 477

  Fly   286 SKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINW-NFRGPRTHRMPMYIRSIFLHYLPAFL 349
            ::...| ..|.|::..|.:  .:|.|....:..|.|.| :...||:......:|.|..:.|...|
  Fly   478 TRYASP-HYVPPMMTAYKV--IMMTTTYCYILHICIIWLDLYPPRSKAPGWLVRVINSNVLRCIL 539

  Fly   350 FMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI 391
            .::....|....:.|.|...|           |::..::|:|
  Fly   540 GLRFSDSTDYCDIQENPWHHM-----------AKILNNLSSI 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	86/432 (20%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	49/258 (19%)
		Cys-loop	152..166	CDD:349833	2/13 (15%)
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505	4/14 (29%)
		Neur_chan_LBD	212..429	CDD:460752	41/234 (18%)