Protein Alignment nAChRbeta1 and nAChRalpha2

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 233/560 - (41%)
• Similarity: 322/560 - (57%)
• Gaps: 70/560 - (12%)

  Fly     5 CKSWLLCSILVLVAF-SLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVN 68
            ||.  ||.:|||:.. ..|.|:.|.:||..||...||:|||||.|.|..|.|:.||...|||::|
  Fly    23 CKP--LCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLN 85

  Fly    69 EKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVL 133
            .|:||:.:||||...|.|::.:||.::|||:..|.:|.:.:|.|||||:|||||.|.|...:..:
  Fly    86 LKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAI 150

  Fly   134 IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN--------F 190
            ::.||:|:|.||||::|||.|||.|||||||||.|||||||::|||:.|...:.||        .
  Fly   151 LHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIG 215

  Fly   191 VDLSDYWKSGTWDIIEVPAYLNVYEGDSNHP----TETDITFYIIIRRKTLFYTVNLILPTVLIS 251
            :||.:|:.|..|||:.|||..:    :..:|    ...||.|.|.:||||||||||||:|.|.||
  Fly   216 IDLREYYPSVEWDILGVPAERH----EKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGIS 276

  Fly   252 FLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILV 316
            :|.||||||||::|||:.|.||||||..:|.||:|:|:|.|||.|||:.||||||.::..:|:::
  Fly   277 YLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVI 341

  Fly   317 TVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPR------------------KTRLRWMM 363
            |:||:|.::|.|.||:|..:|||.|:..||..|.|:.|:                  ||:....:
  Fly   342 TIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQAL 406

  Fly   364 EMPGMSMPAHPHPSYGSPAELPKHISAIG-GKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGD 427
             |..|.|    :....||..|.:....:| |..:.|         |.....||.....|.||.|.
  Fly   407 -MDEMQM----NSGGSSPDSLRRMQGRVGAGGCNGM---------HVTTATNRFSGLVGALGGGL 457

  Fly   428 GCRRESESSDSIL------LSP---------EASKATEAVEFIAEHLRNEDLYIQTREDWKYVAM 477
            ..........|:|      ||.         |..||...|.||..|::.:|.:....:||.:|||
  Fly   458 STLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAM 522

  Fly   478 VIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEI 517
            |:|||.|::|.|.:..||..||.:||.::   |..:.|::
  Fly   523 VMDRLFLWLFMIASLVGTFVILGEAPSLY---DDTKAIDV 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	226/538 (42%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	104/220 (47%)
		Cys-loop	152..166	CDD:349833	11/13 (85%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	106/222 (48%)
		LIC	47..544	CDD:455710	217/514 (42%)
		Cys-loop	169..183	CDD:349832	11/13 (85%)