Protein Alignment nAChRbeta1 and GluClalpha

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 95/464 - (20%)
• Similarity: 174/464 - (37%)
• Gaps: 123/464 - (26%)

  Fly    15 VLVAFSLVSAS---------EDEERLVRDLFRG---YNKLIRP--VQNMTQKVGVRFGLAFVQLI 65
            :|...||.|||         .::|:.|.|...|   |:..|||  :........||..:....:.
  Fly    10 ILYFASLCSASLANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSIS 74

  Fly    66 NVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRL-PPDKVWKPDIVLFNNADGNYEVRYK 129
            .:::........:..|..|.|.:|::|:.. |.:..|.| ..::||.||:...|..:|::.....
  Fly    75 KIDDVTMEYSVQLTFREQWTDERLKFDDIQ-GRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIM 138

  Fly   130 SNVL--IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGS--WTFNGDQVSLALYNNKNF 190
            .||.  |:|.|.||:........:|.:::..:|.|:|.|.::..|  ||.|
  Fly   139 PNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTN-------------- 189

  Fly   191 VDLSDYWKSGTWDIIEV-----------PAYLNVYEGDSNHPTETD----ITFYIIIRRKTLFYT 240
             ||...||.|  |.::|           ..:|..|   .|..|.|.    :...::.:|:..:|.
  Fly   190 -DLVFLWKEG--DPVQVVKNLHLPRFTLEKFLTDY---CNSKTNTGEYSCLKVDLLFKREFSYYL 248

  Fly   241 VNLILPTVLISFLCVLVFYL-----PAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPL-I 299
            :.:.:|..::..:..:.|:|     ||    :|:||::.||::......::..|||.|....: :
  Fly   249 IQIYIPCCMLVIVSWVSFWLDQGAVPA----RVSLGVTTLLTMATQTSGINASLPPVSYTKAIDV 309

  Fly   300 AKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMME 364
            ...:..||:...   |:...::|:..|. .:::..|:..:           ||:.|:...:..::
  Fly   310 WTGVCLTFVFGA---LLEFALVNYASRS-GSNKANMHKEN-----------MKKKRRDLEQASLD 359

  Fly   365 MP----------------------GMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLH 407
            ..                      |...|...||  |.|..|.|.:..              ::|
  Fly   360 AASDLLDTDSNATFAMASQFARGGGQQKPLVRHP--GDPLALEKRLQC--------------EVH 408

  Fly   408 -----HPNC 411
                 .|||
  Fly   409 MQAPKRPNC 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	95/464 (20%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	53/233 (23%)
		Cys-loop	152..166	CDD:349833	4/13 (31%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	95/464 (20%)