Protein Alignment nAChRbeta1 and nAChRalpha4

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 232/527 - (44%)
• Similarity: 326/527 - (61%)
• Gaps: 43/527 - (8%)

  Fly    22 VSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYD 86
            |:.:.|.:||..||...||||:|||.|.|..:.|...|...|||:||.|||||.:|:|:...|||
  Fly     6 VAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70

  Fly    87 YQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSS 151
            |:|:|:..:|||:.:|.:|.|.:|:|||||:||||||:||...:...||..|.|.|.|||||:||
  Fly    71 YKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSS 135

  Fly   152 CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN-------FVDLSDYWKSGTWDIIEVPA 209
            |.|||.|||||:|||::||||||::|.:|.|...:.:.       .||||:::.|..|||:||||
  Fly   136 CEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPA 200

  Fly   210 YLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISI 274
            ..|............||||.|.:||||||||||:|:|.:.||||.||.||||:::||||||.|||
  Fly   201 VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISI 265

  Fly   275 LLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRS 339
            |:||.||.|||.:|:||||||:||:.|||:|..|:.::||.|||:::|.:||.|:||:|..:::.
  Fly   266 LISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKR 330

  Fly   340 IFLHYLPAFLFMKRPR---KTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVM 401
            :|:.:||||||:|||.   :|....:.:......|      |.|...:.:.:|:  |..:.:...
  Fly   331 VFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYP------YYSATNIDRLVSS--GYNNSLPKE 387

  Fly   402 ELSDLHHPN------CKINRKV------NSG----------GELGLGDGCRRESESSDSILLSPE 444
            :||.....|      |:::..|      :|.          |.||:..........|.|..| |:
  Fly   388 DLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCL-PK 451

  Fly   445 ASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYV 509
            ..|:...|.|||||.:.::...:.:|||||||||:|||.|:||.:....||.||::.||.:::
  Fly   452 IHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYD-- 514

  Fly   510 DQDRIIE 516
            |:..|||
  Fly   515 DRIPIIE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	226/509 (44%)
		Neur_chan_LBD	28..236	CDD:280998	106/214 (50%)
		Neur_chan_memb	243..498	CDD:280999	108/279 (39%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	224/507 (44%)
		Neur_chan_LBD	12..227	CDD:280998	106/214 (50%)
		Neur_chan_memb	234..505	CDD:280999	108/279 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447331
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850