Protein Alignment nAChRbeta1 and chrnd

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_996947.1
• Gene: chrnd / 404273
• ZFINID: ZDB-GENE-030131-6665
• Length: 518
• Species: Danio rerio
• Alignment Length: 549
• Identity: 206/549 - (37%)
• Similarity: 307/549 - (55%)
• Gaps: 77/549 - (14%)

  Fly     6 KSWLLCSILVLVAFSLVSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVN 68
            |:.||.:.|:...|.......:||||:..||  |||||.:|||||..:.|.:...|....||::.
Zfish     3 KTVLLTASLLCFIFQECCGRNEEERLINYLFKERGYNKELRPVQNKDETVDIYLALTLSNLISLK 67

  Fly    69 EKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVL 133
            |.::.:.:|||:...|.|::|.|:|::| .|.||||||..||.|:|||.||.|..::|.|..|||
Zfish    68 EVDETLLTNVWMEHGWKDHRLTWNESEY-DIPVLRLPPSMVWLPEIVLENNNDAQFQVAYYCNVL 131

  Fly   134 IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL---YNNKNF----- 190
            ||.:|::.|:||||::|||:|:|.|||||.|.|.:||.|.|:|..::||.|   ..|..:
Zfish   132 IYSSGDMYWLPPAIFRSSCSINVNYFPFDWQNCSLKFSSLTYNAKEISLNLKMEQENTTYYKVEW 196

  Fly   191 --VDLSDYWKSGTWDIIEVPAYLNVYEG---DSNHPTETDITFYIIIRRKTLFYTVNLILPTVLI 250
              :|...:.::|.|:|:..||..|:|:.   :||  ...|||||:||:||.|||.||:|:|.|||
Zfish   197 IIIDPEGFTENGEWEIVHKPARRNIYKSIPKESN--KHQDITFYLIIKRKPLFYIVNIIIPCVLI 259

  Fly   251 SFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSIL 315
            |||..||:||||::|||:||.||:||:..|||||:|:.||.||:.:|||.|||:|..::.||.:|
Zfish   260 SFLASLVYYLPADSGEKMTLSISVLLAQSVFLLLISQRLPETSMAVPLIVKYLMFIMVLVTVVVL 324

  Fly   316 VTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGS 380
            ..||::|.:||.|.||.|..:.:..||..||..|.                 ||:|....|.  .
Zfish   325 NCVIVLNLHFRTPSTHVMTEWTKEFFLERLPRLLH-----------------MSLPVEDQPV--P 370

  Fly   381 PAELPKHISAIG---------GKQSKMEVM--ELSDLH----HPNCKINRKVNSGGELGLGDGCR 430
            .:.||:..|::|         ..:|:.|:|  :.|:.|    .|..|.....::
Zfish   371 ESALPRRSSSLGYIAQAEEYYSVKSRSELMFEKQSERHGLAARPTPKATYTSSN----------- 424

  Fly   431 RESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGT 495
             :||.|:.  |..|...|.|...:|.:|:.:::.|.:.:::|..:|..:|||..|:...|...||
Zfish   425 -DSEVSEQ--LYNEMKPAVEGANYIVKHMHDKNDYNEEKDNWSGIARTVDRLCFYVVTPVMMIGT 486

  Fly   496 VGILMDA-----PHI------FEYVDQDR 513
            :.|.:.|     |.:      |.|.:::|
Zfish   487 ICIFLMANYNQPPALPFQGDPFSYTEENR 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	200/521 (38%)
		Neur_chan_LBD	28..236	CDD:280998	98/222 (44%)
		Neur_chan_memb	243..498	CDD:280999	91/269 (34%)
chrnd	NP_996947.1	LIC	6..493	CDD:273305	200/522 (38%)
		Neur_chan_LBD	25..245	CDD:280998	98/222 (44%)
		Neur_chan_memb	252..490	CDD:280999	91/270 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810