Protein Alignment nAChRbeta1 and Grd

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 470
• Identity: 97/470 - (20%)
• Similarity: 171/470 - (36%)
• Gaps: 151/470 - (32%)

  Fly    31 LVRDLFRGYNKLIRP----------VQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWY 85
            |:.:|.|||:..|||          |..|.:.:|           .::|.:.....:.:.|..|.
  Fly   112 LLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMG-----------PISEVDMTYSMDCYFRQSWV 165

  Fly    86 DYQLQWDEA-DYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSN--VLIYPTGEVLWVPPAI 147
            |.:|.::.| |...:.|..|.  ::||||...:|............|  |.||..|.||:.....
  Fly   166 DKRLAFEGAQDTLALSVSMLA--RIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLT 228

  Fly   148 YQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPA--- 209
            .::.|.:::..||.|.|.|.:||||:.:....|.......:..|.:::..|...:|:::.||
  Fly   229 IKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNL 293

  Fly   210 ----------------------------YLNVYEG------------------------------ 216
                                        .:..:.|
  Fly   294 TDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGS 358

  Fly   217 ------------DSNHPTETD---ITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA-G 265
                        ::|||:|..   :.|:  ::|....:.:.:..|..|:..|..:.|:|..|| .
  Fly   359 GSTTGLSGTITLETNHPSEYSMLMVNFH--LQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATA 421

  Fly   266 EKVTLGISILLSLVVFLLL-----VSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTV------- 318
            ::|:|||:.:|:: .||.|     :.|:..||:|...:   :|.|.||..|:.....|
  Fly   422 DRVSLGITTVLTM-TFLGLEARTDLPKVSYPTALDFFV---FLSFGFIFATILQFAVVHYYTKYG 482

  Fly   319 ------II--------------INWNFRGPRTHR----MPMYIRSIFLHYLPAFLFM-----KRP 354
                  ||              :..:|||....:    :|:.:.:|.:...|..|.|     :||
  Fly   483 SGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRP 547

  Fly   355 RKTRL-RWMMEMPGM 368
            |..|. .|.|::.|:
  Fly   548 RNRRHGLWSMKLLGL 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	97/470 (21%)
		Neur_chan_LBD	28..236	CDD:280998	55/293 (19%)
		Neur_chan_memb	243..498	CDD:280999	42/169 (25%)
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	48/226 (21%)
		LIC	111..670	CDD:273305	97/470 (21%)
		Neur_chan_memb	398..667	CDD:280999	42/169 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030