Protein Alignment nAChRbeta1 and SecCl

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 111/548 - (20%)
• Similarity: 209/548 - (38%)
• Gaps: 135/548 - (24%)

  Fly     8 WLLCSILVLVAFSLVSASEDEE--------------RLVRDLFR--GYNKLIRPVQ------NMT 50
            |:.. ||||..::.|....:||              :|::.|..  .|::|.||.:      .:.
  Fly    11 WITL-ILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLP 74

  Fly    51 QKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGG--IGVLRLPPDKVWKPD 113
            ..|..|..:.|:|  |:|......|.:..|:|.:.|.:|.:...:...  :|...| .:::|.|.
  Fly    75 IVVKTRIYVYFLQ--NLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL-SERLWLPH 136

  Fly   114 IVLFNNADGNYEVRYKSNVL--IYPTGEVL---WVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSW 173
            |...|..:.:.....:.:||  :.|.|.|:   .:..::|   |.::...||||||.|.....||
  Fly   137 IFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLY---CWMNFQKFPFDQQFCSTVLESW 198

  Fly   174 TFN----------------GDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDS---- 218
            .:|                ..::.|..||      ::.:|.:.|  |::       .:||:
  Fly   199 MYNTSDLILEWEPHTPISFDPEMRLTEYN------MAQFWHNTT--IVQ-------SDGDNLRHG 248

  Fly   219 ----NHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG-EKVTLGISILLSL 278
                |:   :.::|.:.::|:..||.::..||:::|..:..:.|:|.|:|. .::.||.|.:||.
  Fly   249 AFAGNY---SSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSF 310

  Fly   279 VVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLH 343
            :......||.||..|.:......:|..||.:  ...||....:|..:|    .:..:.::.:...
  Fly   311 ITLSSSQSKNLPKVSYIKVSEVWFLGCTFFI--FGSLVEFAFVNTIWR----RKENIELKKVNSK 369

  Fly   344 YLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI--GGKQSKMEVMELSDL 406
            |:.......||.:.::...:.....:.......:..|..|..::.:..  .|..:.:.|
  Fly   370 YIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTV------ 428

  Fly   407 HHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTRED 471
             |||..|               .|.|...:|::.:   .|..|           |.|..:...:|
  Fly   429 -HPNLPI---------------IRTECAEADTVSI---CSART-----------NNDHIVDVDKD 463

  Fly   472 WK------------YVAMVIDRLQLYIF 487
            .|            .:||.|||...::|
  Fly   464 KKDTPPTFTTMTPQEIAMWIDRRSRFLF 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	111/548 (20%)
		Neur_chan_LBD	28..236	CDD:280998	53/260 (20%)
		Neur_chan_memb	243..498	CDD:280999	50/260 (19%)
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	103/515 (20%)
		Neur_chan_LBD	44..267	CDD:280998	51/246 (21%)
		Neur_chan_memb	275..503	CDD:280999	50/259 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030