Protein Alignment nAChRbeta1 and pHCl-1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 513
• Identity: 99/513 - (19%)
• Similarity: 178/513 - (34%)
• Gaps: 143/513 - (27%)

  Fly    24 ASEDEERLVRDLF---RGYNK-LIRPV-----------------QNMTQ-----KVGVRFGLAFV 62
            :|.|:|  :.||.   :.|:| |:.||                 ||..:     .:.|...:..:
  Fly   334 SSSDKE--ILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLL 396

  Fly    63 QLINVNEKNQIMKSNVWLRLVWYDYQLQW-DEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEV 126
            .|.:.:|.:...:....|...|.|.:||: :::.|..:..|. ..|.:|.||.....:.|
  Fly   397 SLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALH-HHDSIWTPDTYFIMHGD----- 455

  Fly   127 RYKSNVL-------IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL 184
             :|..::       |:..|.:.:........||...:..||||...|.....|.::...|:....
  Fly   456 -FKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVW 519

  Fly   185 YNNKNFVDLSDYWKSGTWDIIEVPAYL----------NVYEGDSNHPTETDITFYIIIRRKTLFY 239
            .|:::.:..|.       .:..:.|||          |.:.|:.: ..:.::||    .|...:|
  Fly   520 KNDEDTLRKSP-------SLTTLNAYLIKNQTTACDQNSWRGNYS-CLQVELTF----TRDRAYY 572

  Fly   240 TVNLILPTVLISFLCVLVFYL-----PAEAGEKVTLGISILLSLVVFLLLVSKILPPTS-LVLPL 298
            ...:.:|.:::.....:.|:|     ||    :|.:|::.:|:...........||..| |....
  Fly   573 FTTVFIPGIILVTSSFITFWLEWNAVPA----RVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMN 633

  Fly   299 IAKYLLFTFIMNTVSILVTVIIINWNFR-------------GPRTHRMPMYIRSIFLHYLPAFLF 350
            :...:...||   .:.|:..:.:|:..|             .|.|.|:|..:..|       .:.
  Fly   634 VWDGVCMCFI---YASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRI-------GVI 688

  Fly   351 MKRPRKTRLRWMMEMPGMSMPAHPHP-SYGSPAEL-------------PKHISAIGGKQSKMEVM 401
            :..|    |......|.|||.....| |.|:||..             |:..  .||.      |
  Fly   689 LASP----LASAAATPAMSMMGGATPMSSGTPAASSSVATPGTPRITDPEEF--FGGG------M 741

  Fly   402 ELSDLHHPNCKINRKVNSGGELGL------GDGCRRESESSDSILLSPEAS-KATEAV 452
            ...:.|            ||.:|.      ....:|::..|.|..:||..| :.||.:
  Fly   742 RWQEAH------------GGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHI 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	99/513 (19%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	48/252 (19%)
		Cys-loop	152..166	CDD:349833	5/13 (38%)
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	65/350 (19%)
		LGIC_TM	<948..975	CDD:476813
		TM4 helix	950..971	CDD:349850