Protein Alignment nAChRbeta1 and chrna1.2

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_012825723.1
• Gene: chrna1.2 / 394991
• XenbaseID: XB-GENE-5932067
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 507
• Identity: 194/507 - (38%)
• Similarity: 295/507 - (58%)
• Gaps: 61/507 - (12%)

  Fly    11 CSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMK 75
            |.|...:|...|.:|:.|.||:.|||..|||::|||:....:|.|..||..:|||||:|.|||:.
 Frog     7 CLIFFFIAAGPVFSSDHETRLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQLINVDEVNQIVS 71

  Fly    76 SNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEV 140
            :|:.|:..|.|..|:||.|.|||:..||:|..:||.||:||:|||||::.:...:.:|:..||::
 Frog    72 TNIRLKQQWVDVNLKWDPAKYGGVKKLRIPSSEVWCPDLVLYNNADGDFAISKDTKILLEHTGKI 136

  Fly   141 LWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYN-NKNFVDLSDYWKSGTWDI 204
            .|.||||::|.|.|.||:||||||.|.||||:||::|   :|.:.| :::..|||::..||.|.:
 Frog   137 TWTPPAIFKSYCEIIVTHFPFDQQNCSMKFGTWTYDG---TLVVINPDRDRPDLSNFMASGEWMM 198

  Fly   205 IEVPAYLN-VYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKV 268
            .:...:.: ||..........|||::.:::|..|::.||:|:|.:|.|||..||||||.::|||:
 Frog   199 KDYRCWKHWVYYTCCPDKPYLDITYHFVLQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKM 263

  Fly   269 TLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRM 333
            ||.||:||||.||||::.:::|.||..:|||.||:|||.:....||::|||:||.:.|.|.||.|
 Frog   264 TLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHTM 328

  Fly   334 PMYIRSIFLHYLPAFLF---MKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQ 395
            |.::|.||:..:|..:|   ||||              |....|..::.
 Frog   329 PPWVRKIFIDTIPNIMFFSTMKRP--------------SQEKQPQTTFA---------------- 363

  Fly   396 SKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLR 460
               |.|::||:             .|:||.. ....:|.:    |.:|:...|.|.:::|||.::
 Frog   364 ---EEMDISDI-------------SGKLGPA-AVTYQSPA----LKNPDVKSAIEGIKYIAETMK 407

  Fly   461 NEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQD 512
            ::....:..|:||:||||:|.:.|.:|..|...||:.:.  |..|.|...||
 Frog   408 SDQESNKASEEWKFVAMVLDHILLAVFMTVCVIGTLAVF--AGRIIEMNMQD 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	189/493 (38%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	91/210 (43%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
chrna1.2	XP_012825723.1	LIC	8..447	CDD:455710	188/494 (38%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	91/211 (43%)
		Cys-loop	148..162	CDD:349815	10/13 (77%)