Protein Alignment nAChRbeta1 and chrna7a

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_957513.1
• Gene: chrna7a / 394199
• ZFINID: ZDB-GENE-040108-3
• Length: 509
• Species: Danio rerio
• Alignment Length: 524
• Identity: 193/524 - (36%)
• Similarity: 309/524 - (58%)
• Gaps: 43/524 - (8%)

  Fly     3 SSCKSWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINV 67
            ::|..|           |:....|.:.||.|||.:.||.|.|||.|.|..:.|.|.::.:|:::|
Zfish    12 TTCCLW-----------SVSLQGEHQRRLYRDLMKDYNPLERPVFNDTHSLTVYFSMSLMQIMDV 65

  Fly    68 NEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNV 132
            :||||::.:|:||:|.||||.|||:.::|.|:..:|.|..::|||||:|:|:||..::..:.:||
Zfish    66 DEKNQVLTTNIWLQLYWYDYYLQWNASEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNV 130

  Fly   133 LIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYW 197
            |:..:|...::||.|::|:|.|||.:||||.|.|.:||||||:.|..:.|.:.:    .|::.|.
Zfish   131 LVNSSGACQYLPPGIFKSTCYIDVRWFPFDLQRCDLKFGSWTYGGWSLDLQMID----ADITGYI 191

  Fly   198 KSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPA 262
            .:|.||::|||...|....|.......|:||.:::||:||:|.:||::|.||||.|.:|||.|||
Zfish   192 ANGEWDLVEVPGRRNERFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPA 256

  Fly   263 EAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRG 327
            ::|||::|||::||||.||:|||::|:|.||..:||||:|...|.::..:|::.||.::.:::..
Zfish   257 DSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHD 321

  Fly   328 PRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPA-HPHPSYGSPAELPKHIS-- 389
            |...:||.:.|.:.|::...||.||||.:.::|          || |......|.:.:..:||
Zfish   322 PEGGKMPKWTRVVLLNWCAWFLRMKRPGEDKVR----------PACHNKQPRSSLSSVDLNISPG 376

  Fly   390 ---AIGGKQSKMEVMELSDLHH---PNCKI--NRKVNSGGELGLGDGCRRESESSDSILLSP--- 443
               :..|....:....:..:|:   |:..:  :|.|.:|.|..|..|.:..|.||.    .|
Zfish   377 VAQSTNGNLLYIGFRGMDTIHYATSPDSGVICSRLVATGEEDVLLPGAQASSVSSS----GPGET 437

  Fly   444 EASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEY 508
            |.||..:.|.:|::..|::|.......:||:.|.|||||.|..|.:.|...|:||||.||:..|.
Zfish   438 ELSKILDEVRYISKRFRDQDEEDTVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSAPNFVEA 502

  Fly   509 VDQD 512
            :.:|
Zfish   503 ISKD 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	186/505 (37%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	86/208 (41%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrna7a	NP_957513.1	LIC	3..496	CDD:455710	189/512 (37%)