Protein Alignment nAChRbeta1 and Rdl

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 95/496 - (19%)
• Similarity: 177/496 - (35%)
• Gaps: 124/496 - (25%)

  Fly    10 LCSILVLVAFSLVSASEDEERL--------------------VRDLFR-GYNKLIRP-VQNMTQK 52
            |.:|.:.:..:|::.....:|:                    :.|.|. .|:|.:|| ......:
  Fly    20 LLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPVE 84

  Fly    53 VGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPD---KVWKPDI 114
            |||.  :..:.:.:::|.......:.:.|..|.|.:|.:.:..  |:..|.:..:   .:|.||.
  Fly    85 VGVT--MYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRP--GVETLSVGSEFIKNIWVPDT 145

  Fly   115 VLFNNADGNYEVRYKSN--VLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNG 177
            ...|.....:.:...||  :.::.:|.:.........:||.:::.|||.|:|.|.::..|:.:
  Fly   146 FFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGY-- 208

  Fly   178 DQVSLALYNNKNFVDLSDYWKSGTWDI-----IEVPAYLNVYEGDSNHPTETDIT--------FY 229
                       ...|:..:|:.|...:     :|:|.:..:  |.....||.::|        ..
  Fly   209 -----------TMRDIRYFWRDGLSSVGMSSEVELPQFRVL--GHRQRATEINLTTGNYSRLACE 260

  Fly   230 IIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA-GEKVTLGISILLSLVVFLLLVSKILPPTS 293
            |...|...:|.:.:.:|:.||..:..:.|:|...| ..:|.||::.:|::...:...:..||..|
  Fly   261 IQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKIS 325

  Fly   294 LVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTR 358
            .| ..|..||...|:|...|:                           |.|.......||.:..:
  Fly   326 YV-KSIDVYLGTCFVMVFASL---------------------------LEYATVGYMAKRIQMRK 362

  Fly   359 LRWM----------MEMPGMS-MPAHPHP--SYGSPAELPKHISAIGGKQSKMEVMELSDLHHPN 410
            .|:|          .::.|.: ..|:|:|  :.|.|..:.......||               |.
  Fly   363 QRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGG---------------PG 412

  Fly   411 CKINRKV--NSGGELGLGDGCRRESESSDSILLSPEASKAT 449
            ..:|..|  ..|.|.|.|.|....|..      .|.|.|.|
  Fly   413 GGVNVGVGMGMGPEHGHGHGHHAHSHG------HPHAPKQT 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	95/496 (19%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	44/248 (18%)
		Cys-loop	152..166	CDD:349833	6/13 (46%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	36/201 (18%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	47/223 (21%)