Protein Alignment nAChRbeta1 and deg-3

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001379138.1
• Gene: deg-3 / 3565200
• WormBaseID: WBGene00000951
• Length: 564
• Species: Caenorhabditis elegans
• Alignment Length: 567
• Identity: 135/567 - (23%)
• Similarity: 252/567 - (44%)
• Gaps: 107/567 - (18%)

  Fly    21 LVSASEDEE---------RLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIM 74
            |::::.|.:         ||.|.|.  ..|:..:||:.:..:.:.|...::..|:|.|:|.:|.:
 Worm    35 LLNSTADRDIAMKNVPLVRLTRHLLSPERYDVRVRPILDHKKSLKVHISISLYQIIEVDEPSQNI 99

  Fly    75 KSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNN---------------ADGNY 124
            |.|||:...|.|..|.|:..:||.|....:|...:|.||..|:|:               |..||
 Worm   100 KLNVWMIQKWRDEYLDWNPNEYGMINSTIIPFHHLWIPDTYLYNSVKMSRDETERYMNIQATSNY 164

  Fly   125 EVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN 189
            ....|.       .|:.::.||||..:|.:::.:||:|:|.|.:...|||  ..:.:|..|.:..
 Worm   165 WKGEKG-------AELSFLYPAIYTITCRLNIRFFPYDRQNCTLTISSWT--NSKSALDYYADTE 220

  Fly   190 FVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLC 254
             |.:..:..:..|.:.....:.:.|:..........:...::|:||.|:|.||||:||.:|:.:.
 Worm   221 -VSMQSFIPNEEWQVKSFKIHRHEYKYACCAEPWVILQASLVIQRKPLYYLVNLIIPTSIITLVA 284

  Fly   255 VLVFYLPA----EAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSIL 315
            :..|:.||    :..||:.|||:.||::.:.:|:||..:|.||..:||||.:.|...|:.::...
 Worm   285 ITGFFTPASTDDDRTEKINLGITTLLAMSILMLMVSDQMPTTSEFVPLIAWFYLSIIIIISIGTF 349

  Fly   316 VTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRW--MMEMP------------ 366
            :|.::::...|.......|.:||.||...||..|.:..|...:..|  :.:.|
 Worm   350 LTSVVLSVQGRRQYGRNPPQFIRYIFFVLLPQVLLLNVPPPLQTLWGELDDDPLNVRRRKKSHYL 414

  Fly   367 ------GMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGL 425
                  |.:..|.|.    |...:|:...::..|:...::::::..:.||...:|..:
 Worm   415 SRNVNNGSTKMASPM----STLRVPQSAGSVSEKRQSFQMIDVTSPNSPNTARSRAPS------- 468

  Fly   426 GDGCRRESESSDSILLSPEASKAT------EAVEFIAEHLR------NEDLYIQTRE-----DWK 473
                           |:|..:|||      .|:......||      |:::....|:     :|:
 Worm   469 ---------------LAPSTAKATMWEGTMSALAGTNTQLRRTSNVFNKEVDEMRRKRQCSLEWE 518

  Fly   474 YVAMVIDRLQLYIF---FIVTTAGTVGILMDAPHIFEYVDQDRIIEI 517
            ::|.|:||..|.:|   .::.|||.:.:...|.:.:::.| ||...:
 Worm   519 FLATVLDRFLLIVFVGAVVIVTAGLILVGRMAQYSYDHPD-DRFFNV 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	131/548 (24%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	56/234 (24%)
		Cys-loop	152..166	CDD:349833	5/13 (38%)
deg-3	NP_001379138.1	Neur_chan_LBD	53..266	CDD:460752	55/222 (25%)
		LGIC_TM_cation	267..>357	CDD:349853	32/89 (36%)
		TM1 helix	267..291	CDD:349853	10/23 (43%)
		Neur_chan_memb	273..543	CDD:460753	68/295 (23%)
		TM2 helix	303..324	CDD:349853	8/20 (40%)
		TM3 helix	335..357	CDD:349853	3/21 (14%)