Protein Alignment nAChRbeta1 and lgc-8

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001023533.2
• Gene: lgc-8 / 3564870
• WormBaseID: WBGene00013338
• Length: 438
• Species: Caenorhabditis elegans
• Alignment Length: 498
• Identity: 112/498 - (22%)
• Similarity: 211/498 - (42%)
• Gaps: 102/498 - (20%)

  Fly    10 LCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIM 74
            |.|:|:|.....:......|:|...|..||:..||||.|....:.:...:..:..:.::...:.:
 Worm    10 LHSVLILWNLLEIDGITVSEQLKDVLMEGYDSSIRPVINERDTLFINISINSMSFLTLDPAEETI 74

  Fly    75 KSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNY---------EVRYKS 130
            ..:....|.|.|..|.|:::|| .|..|:|....:|.||..:..:.|.||         .|:|..
 Worm    75 NFSGEFILQWKDEFLFWNKSDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIETSERYVSVKYDG 138

  Fly   131 NVL--IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDL 193
            .|.  ||          |::.:.|.:::..||:|||||::|.|.|::...:|:..:..:....:.
 Worm   139 TVRQNIY----------AVFTNLCDMNINEFPYDQQTCMIKMGPWSYTMKEVTCIVGGDIERNET 193

  Fly   194 SDYWKSGT-WDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLV 257
            :..::..: ||...:.:.:...|....:.|.:::.|.:.::|:..||...|::||.:|:.:|:..
 Worm   194 TGKFQGNSEWDFEGIVSSVGETEDPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCIFG 258

  Fly   258 FYLP-AEAG---EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTV 318
            .:.| |..|   |:|.|||:.|||..|.|.:|:..:|.|| .|||:..::|....:..:.:|..|
 Worm   259 LFTPTANHGLREERVNLGITTLLSSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAIGVLFAV 322

  Fly   319 IIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAE 383
            :::..:.|.......|           ||::.          |::.|.            ||...
 Worm   323 LVLTLHQRAHTREWRP-----------PAWML----------WILRMT------------GSSKF 354

  Fly   384 LPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKA 448
            |.::|:.|..|.|..|     .:|:                .|:|         :.|.    ...
 Worm   355 LSRNITKIRHKSSTAE-----RIHY----------------TGEG---------AYLF----KNL 385

  Fly   449 TEAVEFIAEHLRNEDLYIQTREDWKYVAMV--IDRLQLYIFFI 489
            .|:::.:.|:::.||     |:.::.:..|  .|||...:..|
 Worm   386 DESLQSVREYIQEED-----RDYFRELTYVKFFDRLDFLLLLI 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	112/498 (22%)
		Neur_chan_LBD	28..236	CDD:280998	50/219 (23%)
		Neur_chan_memb	243..498	CDD:280999	56/253 (22%)
lgc-8	NP_001023533.2	Neur_chan_LBD	29..237	CDD:280998	50/218 (23%)
		Neur_chan_memb	244..>348	CDD:280999	33/125 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810