DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and ZACN

DIOPT Version :10

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_851321.2 Gene:ZACN / 353174 HGNCID:29504 Length:412 Species:Homo sapiens


Alignment Length:299 Identity:66/299 - (22%)
Similarity:115/299 - (38%) Gaps:63/299 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 VGVRFGLAFV-QLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVL 116
            |.||   .|| .:.||:.....|.|.:.|||.|.|.:|.|:.:.:.. ..:.||.:.:|.|.:.:
Human    62 VDVR---VFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTI 122

  Fly   117 FNNADGNYEVRYKSNVLIYPTGEVLWV------PPA--------------IYQSSCTIDVTYFPF 161
            .                     |.|||      |.|              ..:::|..::.:||.
Human   123 L---------------------EALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPR 166

  Fly   162 DQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDI 226
            |...|              ||:.|...|.....::......:|:.|.....||:..:..|.:..:
Human   167 DHSNC--------------SLSFYALSNTAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLV 217

  Fly   227 -TFYIIIRRK--TLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKI 288
             .|.:.:|.|  .|...:.|::|...:....|....||..|.|::...:::|||.:|....:.:.
Human   218 PCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQA 282

  Fly   289 LPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRG 327
            ||.:|...||:..|.....::..:|.:.||::.....||
Human   283 LPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARG 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:455710 66/299 (22%)
LGIC_ECD_nAChR_proto_beta-like 27..236 CDD:349833 43/206 (21%)
Cys-loop 152..166 CDD:349833 4/13 (31%)
ZACNNP_851321.2 LGIC_ECD_ZAC 60..229 CDD:349795 43/205 (21%)
Cys-loop 157..171 CDD:349795 4/13 (31%)
LGIC_TM 231..407 CDD:476813 23/91 (25%)
TM1 helix 235..255 CDD:349850 3/19 (16%)
TM2 helix 263..284 CDD:349850 4/20 (20%)
TM3 helix 295..317 CDD:349850 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..360
TM4 helix 365..386 CDD:349850
Blue background indicates that the domain is not in the aligned region.

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