Protein Alignment nAChRbeta1 and nAChRbeta3

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 94/396 - (23%)
• Similarity: 172/396 - (43%)
• Gaps: 60/396 - (15%)

  Fly    29 ERLVRDLFRGYNKLIRPV-QNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWD 92
            :||...||..|:..::|| |.....|.:..   .|..|:::|.|..:.::.||.|.|.|.:..|.
  Fly    52 DRLHAGLFTNYDSDVQPVFQGTPTNVSLEM---VVTYIDIDELNGKLTTHCWLNLRWRDEERVWQ 113

  Fly    93 EADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVT 157
            .:.|..|..:.|...:||.|.|.|||..:|.  :..::.|.:...|...|:|||:|.:.|.:::.
  Fly   114 PSQYDNITQITLKSSEVWTPQITLFNGDEGG--LMAETQVTLSHDGHFRWMPPAVYTAYCELNML 176

  Fly   158 YFPFDQQTCIMKFGSW----------TFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYL- 211
            .:|.|:|:|.:|.|||          |..|:.           :|..|..:|..|:|::..|:.
  Fly   177 NWPHDKQSCKLKIGSWGLKVVLPENGTARGES-----------LDHDDLVQSPEWEIVDSRAHFV 230

  Fly   212 -NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE-AGEKVTLGISI 274
             ..|.|        .:.:.:..:|::..||..:..|...|..|.:..|:||.. .|||:.:...:
  Fly   231 SQDYYG--------YMEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLL 287

  Fly   275 LLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRS 339
            ::.:..||:..:::||..|...||:..:...:.:..:||.:|.|::: :...|....|:|..:|.
  Fly   288 IIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVL-YLATGKHKRRLPEALRK 351

  Fly   340 IFLHYLPAFLFM--------KRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELP---KHISAIGG 393
            :...:|..:|.:        .:..||:          .|..||:.........|   .|....|.
  Fly   352 LLHGHLGTWLLLSVFSTTGESQAEKTK----------EMDEHPYEEADEQESSPLGINHTEVPGA 406

  Fly   394 KQSKME 399
            |.::.:
  Fly   407 KANQFD 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	94/396 (24%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	57/219 (26%)
		Cys-loop	152..166	CDD:349833	4/13 (31%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	94/396 (24%)