Protein Alignment nAChRbeta1 and nAChRalpha3

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Alignment Length: 759
• Identity: 248/759 - (32%)
• Similarity: 341/759 - (44%)
• Gaps: 264/759 - (34%)

  Fly    13 ILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            ||||...|..:|:.|.:||..||...||||:|||.|:|..:.||..|...|||:||.|||||.:|
  Fly    11 ILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTN 75

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            :|:...||||:|:|:..:|||:.:|.:|.|.:|:|||||:||||||:||...:...:..||.|.|
  Fly    76 LWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEW 140

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN-------FVDLSDYWKSG 200
            .|||||:|||.|||.|||||:|||:|||||||::|.||.|...:..|       .||||:::.|.
  Fly   141 RPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSV 205

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            .|||:||||..|............||||.|.:||||||||||||:|.:.||||.:||||||:::|
  Fly   206 EWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSG 270

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            |||:|.|||||||.||.||:::|:||||||:||:.|::|||.|::|.||.|||:::|.:||.|:|
  Fly   271 EKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQT 335

  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPR-------KTRLRWMM----------EMPGMSMP------- 371
            |.|..::|::|::.||.||.|:||.       |:..|.|:          ::|.:..|
  Fly   336 HTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMH 400

  Fly   372 ---------AHPHPSY----------------GSPAELPKHISAI------GGKQSKMEVMELSD 405
                     ..||..:                |..:.:..|:|::      ...|.......|.|
  Fly   401 HSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLID 465

  Fly   406 --------------LHHP----------------------------------------------N 410
                          |.||                                              :
  Fly   466 AQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSS 530

  Fly   411 CKIN-------------------------------RKVNS------------GGEL----GLGDG 428
            |..|                               ..|||            .|.:    |:|.|
  Fly   531 CSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAG 595

  Fly   429 ----------------------------------------------------------------- 428
                                                                             
  Fly   596 AACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAA 660

  Fly   429 ---------------------CRRES-----ESSDSIL----LSPEASKATEAVEFIAEHLRNED 463
                                 |:||.     ....::.    ..||..||.:.|.:||:..|.|:
  Fly   661 AAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEE 725

  Fly   464 LYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            ...:.:|||||||||:|||.|:||.|....||.||::.||.:::
  Fly   726 ESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYD 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	246/750 (33%)
		Neur_chan_LBD	28..236	CDD:280998	109/214 (51%)
		Neur_chan_memb	243..498	CDD:280999	120/511 (23%)
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	109/214 (51%)
		Neur_chan_memb	248..>359	CDD:280999	63/110 (57%)
		Neur_chan_memb	<683..760	CDD:280999	29/76 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850