Protein Alignment nAChRbeta1 and chrnb3b

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_775394.1
• Gene: chrnb3b / 317643
• ZFINID: ZDB-GENE-030102-4
• Length: 462
• Species: Danio rerio
• Alignment Length: 491
• Identity: 191/491 - (38%)
• Similarity: 287/491 - (58%)
• Gaps: 60/491 - (12%)

  Fly    18 AFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRL 82
            |...||.:|.|:.|:||||:||.:.:||:.:....|.|||||...||::|:||||:|.:||||..
Zfish    21 AREFVSLAEREDALLRDLFQGYQRWVRPILHANHTVKVRFGLKISQLVDVDEKNQLMTTNVWLYE 85

  Fly    83 VWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAI 147
            .|.||:|:|:..:||||..:|:|.:.:|.|||||:.||||.:|....:..::...|.:.|.|||.
Zfish    86 EWLDYKLRWNPENYGGITFIRVPSESIWLPDIVLYENADGRFEGSIMTKAIVRYNGLITWTPPAS 150

  Fly   148 YQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYL- 211
            |:|:||:|||:||||:|.|.|||||||::|:.|.|.|.|::  ||.||::.:|.|:|:....:.
Zfish   151 YKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVELVLVNHQ--VDRSDFFDNGEWEILSATGHKG 213

  Fly   212 NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILL 276
            :..:|..::|.   ||:..|::|..||||:.||:|.:.:|||.|||||||::.||||:|..|:|:
Zfish   214 SRRDGHYSYPY---ITYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKVSLSTSVLV 275

  Fly   277 SLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT-HRMPMYIRSI 340
            ||.||||::.:|:|.:|.|:|||.:||||..|..|:||:|||.:||.:.|...| |.|..::|::
Zfish   276 SLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHPMSPWVRTL 340

  Fly   341 FLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSD 405
            ||..||..|.| |....|..: .:|...|....|....|.|.  |:     |..|:.:.::|
Zfish   341 FLQRLPDLLCM-RGNTDRYHY-PQMEPQSPDLKPRSKKGPPG--PE-----GDGQALINMLE--- 393

  Fly   406 LHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTRE 470
                                                     :||.:|.:|:.|::.|....:..:
Zfish   394 -----------------------------------------QATNSVRYISRHIKKEHFIREVVQ 417

  Fly   471 DWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIF 506
            |||:||.|:||:.|:.|..|:..||:.|...|..:|
Zfish   418 DWKFVAQVLDRIFLWAFLTVSVLGTILIFTPAVKMF 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	189/483 (39%)
		Neur_chan_LBD	28..236	CDD:280998	93/208 (45%)
		Neur_chan_memb	243..498	CDD:280999	87/255 (34%)
chrnb3b	NP_775394.1	LIC	5..449	CDD:273305	189/485 (39%)
		Neur_chan_LBD	31..235	CDD:280998	93/208 (45%)
		Neur_chan_memb	242..446	CDD:280999	87/256 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820