Protein Alignment nAChRbeta1 and CG6927

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 128/559 - (22%)
• Similarity: 222/559 - (39%)
• Gaps: 125/559 - (22%)

  Fly     8 W-LLCSILVLVAFSLVSASED------------EERLVRDLFRG--YNKLIRPV------QNMTQ 51
            | |:.|||:...::..||.::            :.:|:..|..|  |::|.||:      |.:..
  Fly     3 WSLIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQRLPV 67

  Fly    52 KVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPP--------DK 108
            .|.:|..:.|:|  |:...:...|....|::.:.|.:|     ::..:...|..|        :.
  Fly    68 DVYMRAYIYFMQ--NLEAHDLQFKIYALLQMRYLDPRL-----NFRNVSPKRRQPILGEEHLRNS 125

  Fly   109 VWKPDIVLFNNADGNYEVRYKSNVL--IYPTGEVL---WVPPAIYQSSCTIDVTYFPFDQQTCIM 168
            :|.|.|.|.|..|.:.....:.::|  |.|.|.|:   .:...:|   |.:::..||||:|.|..
  Fly   126 LWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLY---CWLNLKKFPFDEQHCST 187

  Fly   169 KFGSWTFNGDQVSL------------ALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNH- 220
            ...||.:|..::.|            ||:..: || |...|.:.|        .:|....|..|
  Fly   188 VLESWMYNTSELVLHWEQKRPITYDGALHLTE-FV-LQRSWSNET--------VINADLSDLRHG 242

  Fly   221 ---PTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPA-EAGEKVTLGISILLSLVVF 281
               ...:.::|.:.:.|...||.::..||::||..:..:.|:|.| :|..::|||.|.||:.:..
  Fly   243 AFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITL 307

  Fly   282 LLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSI---LVTVIIINWNFRGPRTHRMPMYIRSI-FL 342
            .....|.||..|.:     |.....|:..|:.|   :|....:|..:|  |...:|  ::.: ..
  Fly   308 ASAQGKTLPKVSYI-----KVSEVWFLGCTIFIFGSMVEFAFVNTIWR--RKKSVP--VKKLNSK 363

  Fly   343 HYLPAFL---FMKRPRKTRLRWMMEMPGMSMPAHPHPSYGS----------PAELPKHISAIG-- 392
            |.|.:.|   .::|....|.|   ...|.::  |.....||          ...||  |:.|.
  Fly   364 HILKSTLSPNLLRRRSHARSR---SFSGTAL--HKTADTGSLGGAGFNNYLTVNLP--ITTIKEG 421

  Fly   393 ---GKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEF 454
               .:|....|::..|       :|...::.|.:|........|.:|.|..|:  .:..||:
  Fly   422 QVLDQQRTSRVVQKMD-------VNFVESAFGSMGSAQSTGAISAASSSQTLT--NNNRTES--- 474

  Fly   455 IAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIF---FIV 490
             |.|....||...|....:.:||.||....::|   |:|
  Fly   475 -AGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLSFLV 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	128/559 (23%)
		Neur_chan_LBD	28..236	CDD:280998	54/244 (22%)
		Neur_chan_memb	243..498	CDD:280999	65/274 (24%)
CG6927	NP_572194.1	LIC	3..520	CDD:273305	128/559 (23%)
		Neur_chan_LBD	36..259	CDD:280998	53/242 (22%)
		Neur_chan_memb	270..518	CDD:280999	65/272 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030