Protein Alignment nAChRbeta1 and chrna1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_571520.1
• Gene: chrna1 / 30725
• ZFINID: ZDB-GENE-980526-137
• Length: 456
• Species: Danio rerio
• Alignment Length: 498
• Identity: 193/498 - (38%)
• Similarity: 285/498 - (57%)
• Gaps: 70/498 - (14%)

  Fly    25 SEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQL 89
            ||||.|||:.||.||||::|||.:....|.|..||..:|||:|:|.|||:.|||.|:..|.|..|
Zfish    21 SEDETRLVKTLFTGYNKVVRPVSHFKDPVVVTVGLQLIQLISVDEVNQIVTSNVRLKQQWKDVHL 85

  Fly    90 QWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTI 154
            ||:..|||||..:|:|...:||||:||:|||||::.:.:::.||:..||.:.|.||||::|.|.|
Zfish    86 QWNPDDYGGIRKIRIPSTDLWKPDLVLYNNADGDFAIVHETKVLLEHTGMITWTPPAIFKSYCEI 150

  Fly   155 DVTYFPFDQQTCIMKFGSWTFNGDQVSLALYN-NKNFVDLSDYWKSGTWDIIEVPAYLN-VYEGD 217
            .|.:||||.|.|.||.|:||::|   :|.:.| :.:..|||::.:||.|.:.:..::.: ||...
Zfish   151 VVLHFPFDLQNCSMKLGTWTYDG---NLVIINPDSDRPDLSNFMESGEWVMKDYRSWKHWVYYAC 212

  Fly   218 SNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFL 282
            .......|||::.::.|..|::.||:|:|.:|.|||..||||||.::|||:||.||:||||.|||
Zfish   213 CPDTPYLDITYHFLLLRLPLYFIVNVIIPCMLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFL 277

  Fly   283 LLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPA 347
            |::.:::|.||..:|||.||:|||.|....||::|||:||.:.|.|.||.||.::|.||:..:|.
Zfish   278 LVIVELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVINTHHRSPSTHIMPAWVRKIFIDTIPN 342

  Fly   348 FLF---MKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHP 409
            .:|   ||||.:.|....:                .||:.  .||.|.||.....|    ..|.|
Zfish   343 MMFFSTMKRPSQERQEKRL----------------FPADF--DISDISGKPMPASV----TYHSP 385

  Fly   410 NCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKY 474
                                         |..:|:...|.|.|::||:.:::::......|:||:
Zfish   386 -----------------------------ITKNPDVRSAIEGVKYIADTMKSDEESNNAAEEWKF 421

  Fly   475 VAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEI 517
            ||||:|.:.|.:|..|...||:|:.           ..|:||:
Zfish   422 VAMVLDHILLCVFMAVCIIGTLGVF-----------AGRLIEL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	190/479 (40%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	92/210 (44%)
		Cys-loop	152..166	CDD:349833	8/13 (62%)
chrna1	NP_571520.1	LIC	21..447	CDD:455710	190/490 (39%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	93/211 (44%)
		Cys-loop	148..162	CDD:349815	8/13 (62%)