Protein Alignment nAChRbeta1 and HTR3E

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001243543.1
• Gene: HTR3E / 285242
• HGNCID: 24005
• Length: 482
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 112/510 - (21%)
• Similarity: 186/510 - (36%)
• Gaps: 154/510 - (30%)

  Fly    41 KLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLP 105
            |..|||.|::....|....|...:::|               ||.:..:.|:..:..||..:.:.
Human    67 KPFRPVTNISVPTQVNISFAMSAILDV---------------VWDNPFISWNPEECEGITKMSMA 116

  Fly   106 PDKVWKPDIVLFN---NADGNYEV---------------------------RYKSNVLIYPTGEV 140
            ...:|.|||.:..   :..|..||                           .|.||     .|.:
Human   117 AKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTPKGLTAYVSN-----EGRI 176

  Fly   141 LWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKS-----G 200
            .:..|....|.|.:|:.|||||||.|.:.|.|:.:..|  |:.|...|...:::|..::     |
Human   177 RYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVD--SMLLDMEKEVWEITDASRNILQTHG 239

  Fly   201 TWDII---EVPAYL----NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVF 258
            .|:::   :..|.|    |:|:         .|.||:.|||:...|.:||::|:..:..:..|.|
Human   240 EWELLGLSKATAKLSRGGNLYD---------QIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSF 295

  Fly   259 YLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINW 323
            |||.::|.:|...|::||...||||::|.:||.:.  .|||..|......:...|:|.|:.|
Human   296 YLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFI--- 355

  Fly   324 NFRGPRTH----------RMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSY 378
                  ||          .:|.::.|:.||                   ...||...|..|....
Human   356 ------THLLHVATTQPPPLPRWLHSLLLH-------------------CNSPGRCCPTAPQKEN 395

  Fly   379 GSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSP 443
            ..|...|.|:..:                                       :|.|.|...:..|
Human   396 KGPGLTPTHLPGV---------------------------------------KEPEVSAGQMPGP 421

  Fly   444 EASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRL--QLYIFFIVTTAGTV 496
            ..::.|...|:......:|.....:.|.|...:..:|.:  :||:.|:.::..||
Human   422 AEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITV 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	112/510 (22%)
		Neur_chan_LBD	28..236	CDD:280998	55/236 (23%)
		Neur_chan_memb	243..498	CDD:280999	55/266 (21%)
HTR3E	NP_001243543.1	Neur_chan_LBD	70..273	CDD:280998	54/233 (23%)
		Neur_chan_memb	280..>379	CDD:280999	31/109 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810