Protein Alignment nAChRbeta1 and Chrng

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_062018.1
• Gene: Chrng / 25753
• RGDID: 2354
• Length: 519
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 176/520 - (33%)
• Similarity: 273/520 - (52%)
• Gaps: 62/520 - (11%)

  Fly    13 ILVLVAFSLVSASED-EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKS 76
            :|:|:|..|.:.|.: ||||:.||.|.|:..:||.:..:..|.|...|....||::||:.:.:.:
  Rat    10 LLLLLATCLGAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTT 74

  Fly    77 NVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVL 141
            |||:.:.|.||:|:||..||.|:.:||:|...||:|||||.||.||.:||....|||:.|.|.:.
  Rat    75 NVWIEMQWCDYRLRWDPKDYEGLWILRVPSTMVWQPDIVLGNNVDGVFEVALYCNVLVSPDGCIY 139

  Fly   142 WVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN------FVDLSDYWKSG 200
            |:||||::|||:|.|||||||.|.|.:.|.|.|::..:::|.|.....      |:|...:.::|
  Rat   140 WLPPAIFRSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQLSQEDGQAIEWIFIDPEAFTENG 204

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTE----TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP 261
            .|.|...||.:.:   |...|.|    ..:.||::|:||.|||.:|:|:|.||||.:.:|:::||
  Rat   205 EWAIRHRPAKMLL---DPVTPAEEAGHQKVVFYLLIQRKPLFYVINIIVPCVLISSVAILIYFLP 266

  Fly   262 AEA-GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNF 325
            |:| |:|.|:..::||:..|||.||:|.:|.||..:|||:|||.|..::..:.::.:|:::|.:.
  Rat   267 AKAGGQKCTVATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSL 331

  Fly   326 RGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAEL-PKHIS 389
            |.|.||.|...:|.:||..||..|.|                     |.||.  :||.: ...:.
  Rat   332 RSPHTHSMARGVRKVFLRLLPQLLRM---------------------HVHPR--APAAVQDARLR 373

  Fly   390 AIGGKQSKMEVM--ELSDLHHPNCK--------------INRKVNSGGELGLGDGCRRESESSDS 438
            ...|..|...:|  |..||..|..:              :..|:.:|.|:      |:..|...|
  Rat   374 LQNGSSSGWPIMTREEGDLCLPRSELLFRQRQRNGLVQAVLEKLENGPEM------RQSQEFCGS 432

  Fly   439 I-LLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            : ..||......:|...:|.....:..:....|:|..|..|:||:.......:...||.||.:.|
  Rat   433 LKQASPAIQACVDACNLMARARHQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFLMA 497

  Fly   503  502
              Rat   498  497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	175/516 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	87/219 (40%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
Chrng	NP_062018.1	LGIC_ECD_nAChR_G	49..241	CDD:349830	77/194 (40%)
		Cys-loop	150..164	CDD:349830	10/13 (77%)
		Neur_chan_memb	248..494	CDD:460753	77/274 (28%)