Protein Alignment nAChRbeta1 and Chrna4

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_038960311.1
• Gene: Chrna4 / 25590
• RGDID: 2346
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 616
• Identity: 243/616 - (39%)
• Similarity: 333/616 - (54%)
• Gaps: 130/616 - (21%)

  Fly     9 LLCSILVLVAFSLVSASED-------EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLIN 66
            ||..:|:|:...|:.||..       ||||::.||.||||..|||.|::..|.|||||:..|||:
  Rat   173 LLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLID 237

  Fly    67 VNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSN 131
            |:||||:|.:|||::..|:||:|:||..||..:..:|:|.:.:|:|||||:|||||::.|.:.:.
  Rat   238 VDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTK 302

  Fly   132 VLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDY 196
            ..::..|.|.|.|||||:|||:||||:||||||.|.|||||||:  |:..:.|.:..:.||..|:
  Rat   303 AHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTY--DKAKIDLVSMHSRVDQLDF 365

  Fly   197 WKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP 261
            |:||.|.|::.....|..:.:.......|||:..||||..||||:|||:|.:|||.|.|||||||
  Rat   366 WESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLP 430

  Fly   262 AEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFR 326
            :|.||||||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|.:.|
  Rat   431 SECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHR 495

  Fly   327 GPRTHRMPMYIRSIFLHYLPAFLFMKRPR--KTRLRWMME------------------------- 364
            .||||.||.::|.:||..:|..||||||.  |...|.::|
  Rat   496 SPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDI 560

  Fly   365 --------------------------MPGMSMP---------AHPHPSYGSPAELPKHISAIGGK 394
                                      .|.:.:|         |.|.||.|| ...||..|   |.
  Rat   561 CNQGLSPAPTFCNPTDTAVETQPTCRSPPLEVPDLKTSEVEKASPCPSPGS-CPPPKSSS---GA 621

  Fly   395 QSKMEVMELSDLHHPN----------CK---INRKVNSGGELGLGDG------------------ 428
            ...::...||..|.|:          |:   |...|:..|...|.|.
  Rat   622 PMLIKARSLSVQHVPSSQEAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPV 686

  Fly   429 ----------CRRESESS--------------DSILLSPEASKATEAVEFIAEHLRNEDLYIQTR 469
                      |:..|..|              ..:.|||..::|.|.|::||:||:.||.....:
  Rat   687 SDQASPCKCTCKEPSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVK 751

  Fly   470 EDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            ||||||||||||:.|::|.||...||||:.:
  Rat   752 EDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	243/614 (40%)
		Neur_chan_LBD	28..236	CDD:280998	101/207 (49%)
		Neur_chan_memb	243..498	CDD:280999	129/371 (35%)
Chrna4	XP_038960311.1	LGIC_ECD	199..405	CDD:355788	101/207 (49%)
		Cys-loop	323..337	CDD:349787	11/13 (85%)
		Neur_chan_memb	412..781	CDD:397193	130/372 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H592
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920