DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and Chrna7

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_036964.3 Gene:Chrna7 / 25302 RGDID:2348 Length:502 Species:Rattus norvegicus


Alignment Length:536 Identity:197/536 - (36%)
Similarity:304/536 - (56%) Gaps:75/536 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 WL-LCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            || |.:.|:.|:..    .|.:.||.::|.:.||.|.|||.|.:|.:.|.|.|:.:|:::|:|||
  Rat     9 WLALAAALLHVSLQ----GEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKN 69

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            |::.:|:||::.|.|:.|||:.::|.|:..:|.|..::|||||:|:|:||..::..:.:|||:..
  Rat    70 QVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNA 134

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            :|...::||.|::|||.|||.:||||.|.|.:|||||::.|..:.|.:..    .|:|.|..:|.
  Rat   135 SGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQE----ADISSYIPNGE 195

  Fly   202 WDIIEVPAYLN--VYE-GDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263
            ||::.:|...|  .|| ....:|   |:|:.:.:||:||:|.:||::|.||||.|.:|||.|||:
  Rat   196 WDLMGIPGKRNEKFYECCKEPYP---DVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD 257

  Fly   264 AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGP 328
            :|||::|||::||||.||:|||::|:|.||..:||||:|...|.|:..:|::||||::.::...|
  Rat   258 SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDP 322

  Fly   329 RTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGG 393
            ...:||.:.|.|.|::...||.||||.:.::|          ||..|.        |:..|    
  Rat   323 DGGKMPKWTRIILLNWCAWFLRMKRPGEDKVR----------PACQHK--------PRRCS---- 365

  Fly   394 KQSKMEVMELSDLHHPNCKINRKVNSGGEL------GL-----------GDGCRRE--SESSDSI 439
                :..:|||....|       ..|.|.|      ||           |..|.|.  |.:.|..
  Rat   366 ----LASVELSAGAGP-------PTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEH 419

  Fly   440 LL--------SPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTV 496
            |:        .|:.:|..|.|.:||...|.:|.......:||:.|.|:|||.|..|.:.|...|:
  Rat   420 LMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTI 484

  Fly   497 GILMDAPHIFEYVDQD 512
            ||||.||:..|.|.:|
  Rat   485 GILMSAPNFVEAVSKD 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 190/522 (36%)
Neur_chan_LBD 28..236 CDD:280998 82/210 (39%)
Neur_chan_memb 243..498 CDD:280999 96/281 (34%)
Chrna7NP_036964.3 LIC 4..490 CDD:273305 192/524 (37%)
Neur_chan_LBD 26..230 CDD:280998 82/210 (39%)
Neur_chan_memb 237..486 CDD:280999 96/281 (34%)
Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000250|UniProtKB:P49582 260..267 4/6 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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