Protein Alignment nAChRbeta1 and Chrnb4

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_434693.1
• Gene: Chrnb4 / 25103
• RGDID: 2351
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 212/505 - (41%)
• Similarity: 310/505 - (61%)
• Gaps: 33/505 - (6%)

  Fly    13 ILVLVAFSLVS-----ASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            :|::..|||:.     .:..||:|:.||..  .||.||||..:.:|.:.:|..|:..|||:|||:
  Rat     6 LLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNER 70

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            .|||.:::||:..|.||:|.|:.:.|.|:.:||:|..:||.|||||:|||||.|||...:||::.
  Rat    71 EQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVR 135

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSG 200
            ..|.:.|:|||||:|:|.|:|.:||||||.|.:||.|||::..::.:.|.:....:|  |:..||
  Rat   136 SNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMD--DFTPSG 198

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            .|||:.:|....|...|   |:..|:|:..||:||.||||:|||:|.|||:.|.:||||||::.|
  Rat   199 EWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCG 260

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            ||:||.||:||:|..||||:|||:|||||.:|||.||||||.::.|.||:.||.::|.:.|.|.|
  Rat   261 EKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPST 325

  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQ 395
            |.|..:::..|||.||.|||||||.       :|   :|:...||||....|......::..|..
  Rat   326 HTMASWVKECFLHKLPTFLFMKRPG-------LE---VSLVRVPHPSQLHLATADTAATSALGPT 380

  Fly   396 SKMEVMELSDLHHPNCKINRKVNSGGELGLGD---GCRRESESSDSILLSPEASKATEAVEFIAE 457
            |.      |:|:..:......|.:..:..:..   |..|::....|.....:..:|.|.|.|||:
  Rat   381 SP------SNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSSGRFREDLQEALEGVSFIAQ 439

  Fly   458 HLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            ||.::|......||||:||||:|||.|::|..|...||:|:.:  |.:|:
  Rat   440 HLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFL--PPLFQ 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	210/496 (42%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	92/210 (44%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
Chrnb4	NP_434693.1	LIC	21..483	CDD:455710	206/484 (43%)
		LGIC_ECD	53..230	CDD:475126	79/181 (44%)