DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta1 and Chrna3

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_434692.2	Gene:	Chrna3 / 25101	RGDID:	2345	Length:	499	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	218/509 - (42%)
Similarity:	323/509 - (63%)	Gaps:	53/509 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            :|||:.....||||.|.||.:.||..||::||||.|::..|.::|.::..||:.|:|.||||::|
  Rat    14 MLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETN 78

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            :||:.:|.||:|:|..:||.|:..:|:|.:|:|||||||:|||||:::|..|:..|:..||||.|
  Rat    79 LWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTW 143

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEV 207
            :||||::|||.|||||||||.|.|.||||||:::..::.|.|..:.  ::|.|||:||.|.||:.
  Rat   144 IPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS--MNLKDYWESGEWAIIKA 206

  Fly   208 PAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGI 272
            |.|.:..:.:.......|||:.:.|||..||||:|||:|.:|||||.|||||||::.||||||.|
  Rat   207 PGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCI 271

  Fly   273 SILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYI 337
            |:||||.||||::::.:|.||||:|||.:|||||.|..|:||::||.::|.::|.|.||.||.::
  Rat   272 SVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWV 336

  Fly   338 RSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVME 402
            :::||:.||..:||.||.                       ....:.||..:..|.:.|.:....
  Rat   337 KAVFLNLLPRVMFMTRPT-----------------------SGEGDTPKTRTFYGAELSNLNCFS 378

  Fly   403 LSD-----------------LHHPNCKINRKVNSGGELGLGDGCRRESESSDSIL----LSPEAS 446
            .:|                 .||...||:   |....|....    .|||.|::|    ||||..
  Rat   379 RADSKSCKEGYPCQDGTCGYCHHRRVKIS---NFSANLTRSS----SSESVDAVLSLSALSPEIK 436

  Fly   447 KATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            :|.::|::|||:::.:::..:.::|||||||||||:.|::|.:|...||.|:.:
  Rat   437 EAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	218/507 (43%)
		Neur_chan_LBD	28..236	CDD:280998	99/207 (48%)
		Neur_chan_memb	243..498	CDD:280999	106/275 (39%)
Chrna3	NP_434692.2	LIC	24..490	CDD:273305	215/497 (43%)
		Neur_chan_LBD	29..235	CDD:280998	99/207 (48%)
		Neur_chan_memb	242..489	CDD:280999	107/276 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920