Protein Alignment nAChRbeta1 and Chrna9

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001074573.1
• Gene: Chrna9 / 231252
• MGIID: 1202403
• Length: 479
• Species: Mus musculus
• Alignment Length: 477
• Identity: 172/477 - (36%)
• Similarity: 272/477 - (57%)
• Gaps: 33/477 - (6%)

  Fly    29 ERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDE 93
            ::|..|||..|:..:|||::....:.|...:...|:.:::|:|||:.:.:|:|..|:|..|.||.
Mouse    32 QKLFSDLFEDYSNALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDR 96

  Fly    94 ADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTY 158
            ..|.|:..:|:|.|.||:|||||:|.||........:||::...|.:.|..|||.:|||.:||||
Mouse    97 DQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTY 161

  Fly   159 FPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYE-GDSNHPT 222
            ||||.|.|.:.|||||:||:||.  ::|..:..||||:.:...|::..:||..||.. |..:.|
Mouse   162 FPFDSQQCNLTFGSWTYNGNQVD--IFNALDSGDLSDFIEDVEWEVQGMPAVKNVISYGCCSEP- 223

  Fly   223 ETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSK 287
            ..|:||.::::|::.||.|||::|.||||||..|.|||||.:||||:||::|||::.||.|:|::
Mouse   224 YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAE 288

  Fly   288 ILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMK 352
            |:|.:..| |||.||.:.|..:.|.|..:|::::|.:|.|.....:|.:.:.:.|.|:...||:.
Mouse   289 IMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVY 352

  Fly   353 RPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGK--QSKMEVMELSDLHHPNCKINR 415
            ...::.|          .|.|        ::.|:.|:.:.||  .|.::.....||...  |..|
Mouse   353 DVGESCL----------SPRH--------SQEPEQITKVYGKLPGSNLKASRNKDLSRK--KELR 397

  Fly   416 KVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVID 480
            |:.. .:||...|.   .:::||.....||  .|:.:|:||:.|::.........:||.||.|||
Mouse   398 KLLK-NDLGYQGGI---PQNTDSYCARYEA--LTKNIEYIAKCLKDHKATNSKGSEWKKVAKVID 456

  Fly   481 RLQLYIFFIVTTAGTVGILMDA 502
            |..::|||.:....||.|:..|
Mouse   457 RFFMWIFFAMVFVMTVLIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	171/473 (36%)
		Neur_chan_LBD	28..236	CDD:280998	81/207 (39%)
		Neur_chan_memb	243..498	CDD:280999	85/256 (33%)
Chrna9	NP_001074573.1	LIC	10..474	CDD:273305	170/471 (36%)
		Neur_chan_LBD	31..236	CDD:280998	80/206 (39%)
		Neur_chan_memb	244..474	CDD:280999	85/256 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810