DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and GABRR3

DIOPT Version :10

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_001099050.1 Gene:GABRR3 / 200959 HGNCID:17969 Length:467 Species:Homo sapiens


Alignment Length:323 Identity:75/323 - (23%)
Similarity:124/323 - (38%) Gaps:63/323 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 EDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQ 90
            ||.:..:|..|.|     .||     .||:...:..:.  :::|.|.......:||..|.|.:|.
Human    68 EDNDFAMRPGFGG-----SPV-----PVGIDVHVESID--SISETNMDFTMTFYLRHYWKDERLS 120

  Fly    91 WDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVL--IYPTGEVLWVPPAIYQSSCT 153
            :.......:........|:|.|||...::...........|::  ::|.|.||........:.|.
Human   121 FPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCF 185

  Fly   154 IDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDS 218
            :|.:.||.|.|.|.::..|:.:|.|             ||..|||.|.       ..||..|..|
Human   186 MDFSRFPLDTQNCSLELESYAYNED-------------DLMLYWKHGN-------KSLNTEEHMS 230

  Fly   219 -------NHPTETDITFY------------IIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
                   :....:.:.||            .::||...|:.:....|.:|:..|..:.|::...|
Human   231 LSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRA 295

  Fly   265 -GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYL----LFTFI----MNTVSILVTV 318
             ..:|:|||:.:|::...:..||..:|..| .|..:..||    ||.|:    ...|:.|.||
Human   296 VPARVSLGITTVLTMSTIITAVSASMPQVS-YLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTV 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:455710 75/323 (23%)
LGIC_ECD_nAChR_proto_beta-like 27..236 CDD:349833 49/229 (21%)
Cys-loop 152..166 CDD:349833 6/13 (46%)
GABRR3NP_001099050.1 LIC 55..466 CDD:455710 75/323 (23%)
LGIC_ECD_GABAAR_rho 82..267 CDD:349806 45/211 (21%)
Cys-loop 184..198 CDD:349806 6/13 (46%)
Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:P50573 347..448 4/11 (36%)

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