Protein Alignment nAChRbeta1 and HTR3D

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001157118.1
• Gene: HTR3D / 200909
• HGNCID: 24004
• Length: 454
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 97/500 - (19%)
• Similarity: 165/500 - (33%)
• Gaps: 146/500 - (29%)

  Fly    41 KLIRPVQN--MTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLR 103
            |.|.||.|  :...|.:.|.|:.:.    |..::|...|......|::..:||:..:.|||....
Human    51 KAIGPVTNYSVATHVNISFTLSAIW----NCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSG 111

  Fly   104 LPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVL----------WVP---PAIYQSSCTID 155
            :..:.:|..|:.:..:.|........|..::..|...:          |.|   |::.::.....
Human   112 MATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRARAWRR 176

  Fly   156 VT-YFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSN 219
            :: .|....:|.......|...|.|..                      .|:|....|.||
Human   177 MSRSFQIHHRTSFRTRREWVLLGIQKR----------------------TIKVTVATNQYE---- 215

  Fly   220 HPTETDITFYIIIRR--KTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFL 282
                 ...|::.|||  :...|.||.::|:.::..:..|.||||.|:|......:::||...|||
Human   216 -----QAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFL 275

  Fly   283 LLVSKILPPT------SLVLPL--------IAKYLLFTFIMNTVSILVTVIIINWNFRGPRTH-- 331
            |:::.:||.|      |||.||        ...|......:...|:|.|:.|         ||
Human   276 LMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFI---------THLL 331

  Fly   332 --------RMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHI 388
                    .:|.::.|:.||                   ....|...|..|......|...|.|:
Human   332 HVATTQPLPLPRWLHSLLLH-------------------CTGQGRCCPTAPQKGNKGPGLTPTHL 377

  Fly   389 SAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVE 453
            ..:                                       :|.|.|...:..|..::.|...|
Human   378 PGV---------------------------------------KEPEVSAGQMPGPGEAELTGGSE 403

  Fly   454 FIAEHLRNEDLYIQTREDWKYVAMVIDRL--QLYIFFIVTTAGTV 496
            :......:|.....:.|.|...:..:|.|  :||:.|:.::..||
Human   404 WTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITV 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	96/499 (19%)
		Neur_chan_LBD	28..236	CDD:280998	39/212 (18%)
		Neur_chan_memb	243..498	CDD:280999	54/279 (19%)
HTR3D	NP_001157118.1	Neur_chan_LBD	55..>130	CDD:280998	17/78 (22%)
		LIC	92..452	CDD:273305	85/454 (19%)
		Neur_chan_memb	237..>351	CDD:280999	31/122 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..410		10/85 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900