Protein Alignment nAChRbeta1 and acr-18

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_506868.2
• Gene: acr-18 / 191604
• WormBaseID: WBGene00000057
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 515
• Identity: 137/515 - (26%)
• Similarity: 247/515 - (47%)
• Gaps: 71/515 - (13%)

  Fly    31 LVRDLFRGYNKLIRPVQNMTQ--KVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDE 93
            |...||..|.|.||||:|.::  ||.::|.|.  |::.|:|::||:....||.|.|.|..|.||.
 Worm    33 LYEHLFLDYVKEIRPVRNESESLKVEIKFWLK--QILKVDERDQIVNIYCWLELYWIDETLTWDP 95

  Fly    94 ADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEV-RYKSNVLIYPTGEVLWVPPAIYQSSCTIDVT 157
            ..:|.:..:.:|..|:||||::::|||:.|.|. ..::|.::..||.|:.....|...||.:::.
 Worm    96 KKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEMETNAIVDNTGRVMLFRSMITDISCNLNLQ 160

  Fly   158 YFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIE--VPAYLNVYEGDSNH 220
            .||||||.|.:.|.||:.:|.::.|:.....:.::|  |.::..|.:.:  |..|..:|: ...|
 Worm   161 QFPFDQQICFVTFASWSMDGSKLDLSATPKTDNLEL--YIRNTEWGLTDFRVKIYQKIYD-CCPH 222

  Fly   221 PTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP----AEAGEKVTLGISILLSLVVF 281
            |. .|:|:::::||...:|..:|::|:..|:.:.::.|:.|    .|..|||:||::.|||:.:.
 Worm   223 PF-PDVTYFMVLRRSPSYYIFSLVIPSAFITVVTIVGFFTPHSTTGENTEKVSLGVTALLSMAII 286

  Fly   282 LLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLP 346
            :::||..:|.||.|:|||.||.:....:..::...|.:.:::..||.....:...:|..|.:.:.
 Worm   287 MMMVSDEVPATSEVIPLIGKYYIGLIFLIFMAAFTTTLTLSYQMRGNSGQEVDPRVRDFFFYQIA 351

  Fly   347 -------AFLFMKRPRKTRLR------------WMMEMPGMSMPA-HPHPSYGSPAELPKHISAI 391
                   ||.| :.|:|. ||            ....:.|.|..| ||:.   .||.:.|.....
 Worm   352 ANPCISWAFSF-QLPKKL-LRSDHRKQSFFFTNGAAHVNGYSKGALHPNT---PPAHIVKMEEIT 411

  Fly   392 GGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIA 456
            ||...|..||.                             :..::.|.||:....|....::.:.
 Worm   412 GGGSVKSFVMS-----------------------------QESAATSTLLTSSLMKIKVVLDDMK 447

  Fly   457 EHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGIL--MDAPHIFEYVDQDRI 514
            ..:..|....:.:.:|:.|..:|||..::.:.::|.|..:.:|  .|.|.:...:..|.:
 Worm   448 ASIHAERELKRIKFEWQQVTRLIDRCIMFSYILITIAFAMVMLASRDPPIVLNDLIMDSV 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	134/499 (27%)
		Neur_chan_LBD	28..236	CDD:280998	70/209 (33%)
		Neur_chan_memb	243..498	CDD:280999	62/278 (22%)
acr-18	NP_506868.2	Neur_chan_LBD	33..237	CDD:280998	70/209 (33%)
		Neur_chan_memb	244..486	CDD:280999	62/275 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810