Protein Alignment nAChRbeta1 and acr-11

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_491906.1
• Gene: acr-11 / 191599
• WormBaseID: WBGene00000050
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 508
• Identity: 183/508 - (36%)
• Similarity: 284/508 - (55%)
• Gaps: 64/508 - (12%)

  Fly     9 LLCSI--LVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            |:.||  ||::..:|...|..|.:|..||.:|||.|.|||||.:|.:.|:..|...|:::|:|||
 Worm     5 LINSILSLVIIHSNLCDGSVAETKLFTDLLKGYNPLERPVQNSSQPLEVKIKLFLQQILDVDEKN 69

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLP--PDKVWKPDIVLFNNADGNYEVRYKSNVLI 134
            ||:..|.||...|:|::|||:...||||..:|.|  .|.:||||::|:|:|..:::..:|||:|.
 Worm    70 QIVSVNAWLSYTWFDHKLQWEPKKYGGIQDIRFPGSSDHIWKPDVLLYNSAAEDFDSTFKSNLLT 134

  Fly   135 YPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN---FVDLSDY 196
            |.||.|:|:||.:.:..|.:|||:||||.|.|.||||||||:|..:.|.:.::.|   .:|||.|
 Worm   135 YHTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQIDDDTNGTQSMDLSTY 199

  Fly   197 WKSGTWDIIEVPA--YLNVYE-GDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVF 258
            ..:|.|.:|...|  .::.|: ....:||   :.:|:.|||:||:|..|||:|::|||.:.:|.|
 Worm   200 LVNGEWQVISTNAKRVVSYYKCCPEPYPT---VNYYLHIRRRTLYYGFNLIIPSLLISLMAILGF 261

  Fly   259 YLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINW 323
            ..|.:||||:||.::|||::|.||.:||::.||||..:|||..:.....::.:.|::.|::::|.
 Worm   262 MFPPDAGEKITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVSASVVFTIVVLNL 326

  Fly   324 NFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHI 388
            :||...:|.|...:|.:.|.:||..|||.||
 Worm   327 HFRSADSHEMNPLVRRVLLEFLPWLLFMSRP---------------------------------- 357

  Fly   389 SAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVE 453
               |.|..|..|::.:|      |:.:|..:..:..|..  ......:..:||.   |..||...
 Worm   358 ---GYKFVKANVIDSTD------KMPKKPKNPLDCNLPS--NHAGYEAQILLLH---SVHTELRR 408

  Fly   454 FIAEHLRNE-DLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHI 505
            .:|.:.:.| |..|||  ||::.|||:||..|.:|.:......:.|:|.||||
 Worm   409 VVAFYNKEEHDERIQT--DWRFAAMVVDRACLLLFTVFIVISILAIMMSAPHI 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	178/501 (36%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	92/216 (43%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
acr-11	NP_491906.1	LIC	25..456	CDD:455710	172/483 (36%)
		LGIC_ECD_nAChR	51..238	CDD:349798	77/189 (41%)
		Cys-loop	152..166	CDD:349798	9/13 (69%)