Protein Alignment nAChRbeta1 and acr-10

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_508692.3
• Gene: acr-10 / 191598
• WormBaseID: WBGene00000049
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 175/570 - (30%)
• Similarity: 295/570 - (51%)
• Gaps: 89/570 - (15%)

  Fly     8 WLLCSILVLVAFSLVS-ASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            ::||...:|....:.| .|:.|.:|.||:.:||.||.|||:.....:.|...:...|::|::.:|
 Worm     6 FVLCLFFILSLIIIESECSKAENKLYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNLDGQN 70

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLP--PDKVWKPDIVLFNNADGNYEVRYKSNVLI 134
            ||::.|.||:.||.||:||||...|..|..:|..  .:::|:|||:|:|:|..:::..:|||.::
 Worm    71 QIIEVNAWLKYVWMDYRLQWDPLQYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKSNEVV 135

  Fly   135 YPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALY----NNKNFVDLSD 195
            |.||||.|:||.|:::||.:|:||||||.|.|.:||||||::|..:.|::.    :::..:|||.
 Worm   136 YNTGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSIIAEEDDSELSIDLST 200

  Fly   196 YWKSGTWDIIEVPAYLNV-YEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFY 259
            |..||.|.:.:.||..:| |......|..| :|||:.:||:||||..|:|||::|||.:.::.|.
 Worm   201 YTPSGEWHLTKAPAVKDVKYNSCCKEPYST-VTFYMFLRRRTLFYLFNIILPSLLISIMTLMGFC 264

  Fly   260 LPA-EAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINW 323
            ||| :..||:....:||||:..|:.:||::.||||..:||:..:.....::::||...|:.::|:
 Worm   265 LPAHDMSEKIGYQTTILLSICFFVTIVSEMTPPTSESVPLLGMFFSSLTLISSVSTAFTITVLNF 329

  Fly   324 NFRGPRT-HRMPMYIRSIFLHYLPAFLFMKRP------RKTRLRWMMEMPGMS------MPAHPH 375
            .:|..:. |..|::.: :||.::|..|.||||      |:..::...|:....      .|..|.
 Worm   330 RYRQVQNIHMHPIFYK-VFLIWIPWLLLMKRPGVFYKKRRATVQAREEISFFDNGDDDCCPKPPE 393

  Fly   376 PSYGSPAE------LPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDG------ 428
            ..|....:      ||.....:   ..||..:....||     ::|||        |||
 Worm   394 FDYSLSIDSADTLPLPPRPKPL---LKKMHSVPAEHLH-----LDRKV--------GDGILKSQR 442

  Fly   429 -----------------------------C-------RRESESSDSILLSPEASKATEAVEFIAE 457
                                         |       :..:.|:.|:::.....:..|.::.:..
 Worm   443 RPLVLTKNVNKSHSLRSRRFTQFEKYIKKCIDDAKLRKNSTYSTYSMMIITYYRQIDEMLKLLNR 507

  Fly   458 HLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            .|..:..|:..:||||:.||.:|||.|.:..::......|:::..|| ||
 Worm   508 RLDKQRKYLFKQEDWKFAAMALDRLCLLLITLLIVMCLFGMILSTPH-FE 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	171/561 (30%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	87/215 (40%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
acr-10	NP_508692.3	LGIC_ECD_nAChR	52..240	CDD:349798	75/188 (40%)
		Cys-loop	153..167	CDD:349798	9/13 (69%)
		LGIC_TM_cation	242..>332	CDD:349853	33/89 (37%)
		TM1 helix	242..266	CDD:349853	11/23 (48%)
		TM2 helix	275..296	CDD:349853	7/20 (35%)
		TM3 helix	307..329	CDD:349853	3/21 (14%)