Protein Alignment nAChRbeta1 and acr-9

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_510285.2
• Gene: acr-9 / 191597
• WormBaseID: WBGene00000048
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 543
• Identity: 186/543 - (34%)
• Similarity: 298/543 - (54%)
• Gaps: 62/543 - (11%)

  Fly     9 LLCSILVLVAFSL---VSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            |..:.|..|.|.|   |.:|.||.||:.||...|:...|||.|.::.:.|...:...|:::|:||
 Worm     6 LRLTALHCVLFHLLTEVHSSADEYRLLADLRHNYDPYERPVANASEPLVVSVKIYLQQILDVDEK 70

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLP--PDKVWKPDIVLFNNADGNYEVRYKSNVL 133
            ||::....|:...|.||:|:||.::||||..:|:|  .:.:||||::|:|:||.|::..|..|.:
 Worm    71 NQVITLVAWIEYQWTDYKLKWDPSEYGGIKDIRIPGNANAIWKPDVLLYNSADENFDSTYPVNYV 135

  Fly   134 IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALY--NNKNF----VD 192
            :..||:||.|||.|.:.||.||:||||||.|.|.:||||||::|:.:.|.:.  ..||.    :|
 Worm   136 VSYTGDVLQVPPGILKLSCKIDITYFPFDDQICHLKFGSWTYSGNFIDLRINGPEGKNISDEGID 200

  Fly   193 LSDYWKSGTWDIIEVPA--YLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCV 255
            :..|.::|.|:::.|||  ..|::: :..:|:   :.||:||:|:||:|.:|||:|:.|||.:.|
 Worm   201 VQYYVQNGEWNLLAVPARHETNIFD-EQPYPS---LFFYLIIQRRTLYYGLNLIIPSFLISLMTV 261

  Fly   256 LVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVII 320
            |.|.||.:||||:||.|:||||:..||.:|:.:.||||..:|||..:.....::.:.|::.||::
 Worm   262 LGFTLPPDAGEKITLEITILLSVCFFLSMVADMTPPTSEAVPLIGAFFSCCMLVVSASVVFTVLV 326

  Fly   321 INWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKT--------------RLRWMMEMPGMSMP 371
            :|.:.|.|.||.|..::|.:.|.:||..|.|:||.||              :.:......|:. |
 Worm   327 LNLHNRKPETHEMSPFLRELLLIWLPWLLLMRRPGKTIFNCTHLKAEKAEEKAKQGSIKNGVG-P 390

  Fly   372 AHP----HPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPN------CKINRKVNSGGELGLG 426
            ..|    |||.|  ..|.|:|..  |:|..::......:.|.:      .::..:|.....:.
 Worm   391 GKPTDSVHPSEG--LSLMKNIKL--GRQQTIDFEYEFHVQHNHLMPVAPSEMTPRVTYSKVMA-- 449

  Fly   427 DGCRRESESSDSIL--LSPEASKATEAVEFIAEHLR-------NEDLYIQTREDWKYVAMVIDRL 482
                 ||...|.::  |:....||...::.|:...|       .::...|...|||:.|||:||.
 Worm   450 -----ESYVEDVVMTELNKYMQKACLELKNISSQTRAMRKKMEEDERDEQAANDWKFAAMVVDRC 509

  Fly   483 QLYIFFIVTTAGTVGILMDAPHI 505
            .|..|.:.....|.||:..:||:
 Worm   510 CLITFSVFIVVSTCGIMFSSPHL 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	184/536 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	86/218 (39%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
acr-9	NP_510285.2	LIC	28..525	CDD:455710	174/512 (34%)
		Neur_chan_LBD	28..242	CDD:460752	85/217 (39%)