Protein Alignment nAChRbeta1 and acr-5

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 517
• Identity: 123/517 - (23%)
• Similarity: 228/517 - (44%)
• Gaps: 106/517 - (20%)

  Fly    27 DEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQL 89
            |:.|||.:|.  ..|.|.:.|.::.|:...|...::..|:::|:|..|.::.|||:...|||..|
 Worm   103 DQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFL 167

  Fly    90 QWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLI---YPTG---------EVLW 142
            .|:..|||.|....:|..::|.||..|:|:.:...:   |:..|:   ..||         :|..
 Worm   168 DWNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQK---KTESLMNAQLETGHWNQKKDGAKVQL 229

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEV 207
            :.||||:.||.:||.:||:|:|.|.....|||.  |:.::..:...:.|:|.:..::..|::|..
 Worm   230 MFPAIYKLSCRMDVRWFPYDRQNCTFIISSWTH--DKQTIDYWPLSSTVNLGNMARNDEWEVISF 292

  Fly   208 PAYLNVYEGDSNHPTETDITF------------YIIIRRKTLFYTVNLILPTVLISFLCVLVFYL 260
             .::.|.|           ||            :::||||.|:|.:||::||.:|:.:.|..|:.
 Worm   293 -EFVRVEE-----------TFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFT 345

  Fly   261 P----AEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKY---LLFTFIMNTVSILVTV 318
            |    :|..||:.|||:.||::.|.:|:|...:|.||..:||::.|   ::...::.|  .|.|.
 Worm   346 PTSSSSERDEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGT--FLATG 408

  Fly   319 IIINWNFRGPRTHRMPM--YIRSIFLHYLPAFLFMKRPRKTRLRWM------------------- 362
            ::.   ..|.:.:..|:  .||.:..:.:..|..:..|......|.
 Worm   409 VLA---IHGQKHYNKPISDRIRKLIYNPVVEFFILSPPTSLIDLWTEFGVISEQRHSTHLDPLLL 470

  Fly   363 --MEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGL 425
              |:....:..|.|...:||.:.....:.:.....:::..:......|...|..||
 Worm   471 QHMDPISHTTRADPQHFFGSISSQMCDLQSTYSYTARLATITRQYTQHAKMKALRK--------- 526

  Fly   426 GDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIF 487
                       :...:|.:.|:        |..::.:.:..:...:|:::|.|:||:.|.||
 Worm   527 -----------NQYRMSMDTSQ--------ARGVKKQKMQRRCSLEWEFLANVLDRILLTIF 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	123/517 (24%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	65/234 (28%)
		Cys-loop	152..166	CDD:349833	7/13 (54%)
acr-5	NP_001367477.1	LIC	104..581	CDD:455710	122/516 (24%)
		Neur_chan_LBD	104..321	CDD:460752	64/233 (27%)