Protein Alignment nAChRbeta1 and lgc-7

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_502777.2
• Gene: lgc-7 / 190370
• WormBaseID: WBGene00013300
• Length: 439
• Species: Caenorhabditis elegans
• Alignment Length: 495
• Identity: 117/495 - (23%)
• Similarity: 216/495 - (43%)
• Gaps: 97/495 - (19%)

  Fly     7 SWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            ||  |::|.:...::.      |:|...|..||:..||||.|....:.:...:..:.::.::...
 Worm    15 SW--CNLLEVDGITVA------EQLKDVLMEGYDSSIRPVNNERDILIINISMNTMSVLTLDPAE 71

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEV----RYKSNV 132
            :.:..:....|.|.|..|.|:::|| .|..|:|....:|.||..:..:.|.||.:    ||   |
 Worm    72 ETINFSSEFILQWKDEFLFWNKSDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIDASERY---V 132

  Fly   133 LIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNN--KNFVDLSD 195
            .:...|.|.....|::.:.|.::|..||:|||||::|.|.|::...:|:..:..:  .|..|..|
 Worm   133 SVKHDGTVRQSIYAVFTNLCDMNVDKFPYDQQTCMIKMGPWSYTTQEVTCIVGRDIAPNDTDFGD 197

  Fly   196 YWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYL 260
            :..:..||...:.:.:...|....:.|.:::.|.:.::|:..||...|::||.:|:.:|:...:.
 Worm   198 FHGNSEWDFEGIVSSVGETEDPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCIFGLFT 262

  Fly   261 P-AEAG---EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIII 321
            | |..|   |:|.|||:.|||..|.|.:|:..:|.|| .|||:..::|....:..:.:|..|:::
 Worm   263 PTANHGLREERVNLGITTLLSSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAIGVLFAVLVL 326

  Fly   322 NWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPK 386
            ..:.|.......|           ||::.          |::.|.            ||...|.:
 Worm   327 TLHQRAHTREWRP-----------PAWML----------WILRMT------------GSSKFLSR 358

  Fly   387 HISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEA 451
            :|:.|..|.|..|     .:|:                .|:|         :.|.    ....|:
 Worm   359 NITKIRHKSSTAE-----RIHY----------------TGEG---------AYLF----KNLDES 389

  Fly   452 VEFIAEHLRNEDLYIQTREDWKYVAMV--IDRLQLYIFFI 489
            ::.:.|:::.||     |:.::.:..|  .|||...:.||
 Worm   390 LQSVREYIQEED-----RDYFRELTYVKFFDRLDFLLLFI 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	116/494 (23%)
		Neur_chan_LBD	28..236	CDD:280998	54/213 (25%)
		Neur_chan_memb	243..498	CDD:280999	57/253 (23%)
lgc-7	NP_502777.2	LIC	6..437	CDD:273305	117/495 (24%)
		Neur_chan_LBD	28..238	CDD:280998	54/219 (25%)
		Neur_chan_memb	245..>349	CDD:280999	33/125 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810