Protein Alignment nAChRbeta1 and pbo-5

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001024240.1
• Gene: pbo-5 / 189903
• WormBaseID: WBGene00012857
• Length: 509
• Species: Caenorhabditis elegans
• Alignment Length: 477
• Identity: 119/477 - (24%)
• Similarity: 205/477 - (42%)
• Gaps: 97/477 - (20%)

  Fly    55 VRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNN 119
            |.:.|..|.::.::|..|.|...:::...|.|..|.||.|.:|||....:|.||:|.|||::||
 Worm    90 VEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTWDPALFGGITKTWIPLDKIWVPDIIVFN- 153

  Fly   120 ADGNYEVRYKSNVL--------------IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKF 170
                   ..|||.|              |:..|.::...||::..||.|::.:||.|.|.|.::.
 Worm   154 -------MVKSNRLAHEDLLSAVRAPARIHYNGTIVASHPAVHTVSCEINIRHFPLDDQRCAIEI 211

  Fly   171 GSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHP--TETDITFYIIIR 233
            .||.:..:::.|..:.:.:   |..|.::..|.::.    |||.|....|.  ..:::.|.|.::
 Worm   212 ASWAYGQEKIRLHAHTDHS---LEHYKRNEEWHLLN----LNVSEEKYEHEGVEVSEVKFEISLK 269

  Fly   234 RKTLFYTVNLILPTVLISFLCVL----VFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSL 294
            |:.|||.|.|..|:.::..:.|:    .|....|..|:.|||::.:|::.|..|:||:.:|.:|.
 Worm   270 RRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERFTLGVTAILTMAVLSLVVSEKVPHSST 334

  Fly   295 VLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMY--------IRSIFLHYLPAFLFM 351
            .:||:..|.||..::.:::.:.|.|::       :.||:..|        :|...|.  |.|...
 Worm   335 HVPLLVAYFLFNMVIVSIAAMTTGIVM-------KVHRLGRYGDEPSDFWMRCFLLK--PVFRTS 390

  Fly   352 KRPRKTRLRWMMEMPGMSMPAHPHP----SYGSPAE-LPKHISAIGGKQSKMEVMELSDLHHPNC 411
            .| ||.|:.          |..|..    |.....| |.|..:.:.|...| |:|..|.|.....
 Worm   391 NR-RKYRMN----------PEEPTQVILVSEAKNGEVLTKKSTELNGTVVK-EIMLSSRLEALEE 443

  Fly   412 KINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVA 476
            .|.:.||.         |.......|.|       .|.|.:|.:..  |:.:.|::
 Worm   444 YIRKMVNR---------CETIKWELDEI-------DAAENIELVRR--RSTNGYVR--------- 481

  Fly   477 MVIDRLQLYIFFIVTTAGTVGI 498
             :.:||.:...|:..:..|:.:
 Worm   482 -ISERLDILFMFLFLSTVTIPV 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	119/477 (25%)
		Neur_chan_LBD	28..236	CDD:280998	54/196 (28%)
		Neur_chan_memb	243..498	CDD:280999	61/271 (23%)
pbo-5	NP_001024240.1	Neur_chan_LBD	68..272	CDD:280998	54/196 (28%)
		Neur_chan_memb	306..>364	CDD:280999	18/64 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910