Protein Alignment nAChRbeta1 and lgc-1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 367
• Identity: 83/367 - (22%)
• Similarity: 160/367 - (43%)
• Gaps: 66/367 - (17%)

  Fly    27 DEERLVRDLFRGYNKLIRPVQ--------NMTQKV-----GVRFGLAFVQLINVNEKNQIMKSNV 78
            |::||..|||:.|:..:..:.        |.|..:     .::..:|.::|::|.|..:.:....
 Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDVVEVEEKVTFLF 79

  Fly    79 WLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVR-YKSNVLIYPTGEVLW 142
            .....|.|.:|:|:..:||||..:.:|...:|.|::.:   ||. :||: ::|:    ......|
 Worm    80 DYLAEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADA-HEVKFFESD----DAPRTAW 136

  Fly   143 V----PPAIYQSS-----CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSD--- 195
            :    ....|.|:     |.:||..||.|:..|          |..|....|....:|..||
 Worm   137 INYNGTTGFYTSTVSSVICQLDVYKFPLDRHEC----------GVSVLFHTYFADEYVIKSDMEP 191

  Fly   196 ------YWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLC 254
                  ...:|.|.:    .|:.|.|...|........|...|.|...||...:::|...|:||.
 Worm   192 LPKPLSQLGNGEWKV----TYIGVAEEIGNGNFSAVQRFVARIERNPGFYVTLVMVPAFFINFLS 252

  Fly   255 VLVFYLPAE-AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLL--FTFIMNTVSILV 316
            ::...|..| .|||:|:|::.::::...|:::::.||.|..: ||:|.|::  ...:|.::.:::
 Worm   253 IIALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTKRI-PLLAIYVIVGLVIVMASIGVVL 316

  Fly   317 TVIIINWNFR--------GPRTHRMPMYIRSIFLHYLPAFLF 350
            |:.:|..:.:        .|...|...:...:.:.|:..|:|
 Worm   317 TLPLIRNHLKKRQKGKEEKPVETRFSKWFGWLTVEYVVMFVF 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	83/367 (23%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	54/240 (23%)
		Cys-loop	152..166	CDD:349833	6/13 (46%)
lgc-1	NP_504154.5	LIC	84..>335	CDD:455710	65/273 (24%)