Protein Alignment nAChRbeta1 and lgc-1

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 367
• Identity: 83/367 - (22%)
• Similarity: 160/367 - (43%)
• Gaps: 66/367 - (17%)

  Fly    27 DEERLVRDLFRGYNKLIRPVQ--------NMTQKV-----GVRFGLAFVQLINVNEKNQIMKSNV 78
            |::||..|||:.|:..:..:.        |.|..:     .::..:|.::|::|.|..:.:....
 Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDVVEVEEKVTFLF 79

  Fly    79 WLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVR-YKSNVLIYPTGEVLW 142
            .....|.|.:|:|:..:||||..:.:|...:|.|::.:   ||. :||: ::|:    ......|
 Worm    80 DYLAEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADA-HEVKFFESD----DAPRTAW 136

  Fly   143 V----PPAIYQSS-----CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSD--- 195
            :    ....|.|:     |.:||..||.|:..|          |..|....|....:|..||
 Worm   137 INYNGTTGFYTSTVSSVICQLDVYKFPLDRHEC----------GVSVLFHTYFADEYVIKSDMEP 191

  Fly   196 ------YWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLC 254
                  ...:|.|.:    .|:.|.|...|........|...|.|...||...:::|...|:||.
 Worm   192 LPKPLSQLGNGEWKV----TYIGVAEEIGNGNFSAVQRFVARIERNPGFYVTLVMVPAFFINFLS 252

  Fly   255 VLVFYLPAE-AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLL--FTFIMNTVSILV 316
            ::...|..| .|||:|:|::.::::...|:::::.||.|..: ||:|.|::  ...:|.::.:::
 Worm   253 IIALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTKRI-PLLAIYVIVGLVIVMASIGVVL 316

  Fly   317 TVIIINWNFR--------GPRTHRMPMYIRSIFLHYLPAFLF 350
            |:.:|..:.:        .|...|...:...:.:.|:..|:|
 Worm   317 TLPLIRNHLKKRQKGKEEKPVETRFSKWFGWLTVEYVVMFVF 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	83/367 (23%)
		Neur_chan_LBD	28..236	CDD:280998	53/239 (22%)
		Neur_chan_memb	243..498	CDD:280999	27/119 (23%)
lgc-1	NP_504154.5	Neur_chan_LBD	84..>335	CDD:332142	65/273 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810